Results 171 to 180 of about 3,227,851 (305)

Engineering tandem VHHs to target different epitopes to enhance antibody‐dependent cell‐mediated cytotoxicity

FEBS Open Bio, EarlyView.
Tandem VHH targeting distinct EGFR epitopes were engineered into a monovalent bispecific antibody (7D12‐EGA1‐Fc) with more potent ADCC without increasing affinity to EGFR. Structural modeling of 7D12‐EGA1‐Fc showed cross‐linking of separate EGFR domains to enhance CD16a engagement on NK cells.
Yuqiang Xu, Hao Jiang, Limin Chen, Fulai Zhou, Ying Jin, Mark L. Chiu   +5 more
wiley   +1 more source

The Social Construction of the Child's Body and Its Relationship with Football Practice. [PDF]

Sports (Basel)
Pedro GM, Luisa LP, Javier RI, María ML, Antonio MM.   +4 more
europepmc   +1 more source

La construction sociale du genre comme construction sociale

, 2021
Faut-il distinguer sexe et genre ? Cet article ne répond pas à la question mais réfléchit aux manières dont le monde y répond et aux implications de ces réponses pour l’analyse des transformations du rapport entre vérité et subjectivité. Il revient d’abord sur les tentatives pour rendre compte de la genèse historique conjointe du genre et du sexe et ...
openaire   +1 more source

FGFR Like1 drives esophageal cancer progression via EMT, PI3K/Akt, and notch signalling: insights from clinical data and next‐generation sequencing analysis

FEBS Open Bio, EarlyView.
Clinical analysis reveals significant dysregulation of FGFRL1 in esophageal cancer (EC) patients. RNAi‐coupled next‐generation sequencing (NGS) and in vitro study reveal FGFRL1‐mediated EC progression via EMT, PI3K/Akt, and Notch pathways. Functional assays confirm its role in tumor growth, migration, and invasion.
Aprajita Srivastava, Anoop Saraya, Deepak Gunjan, Rinu Sharma   +3 more
wiley   +1 more source

"Vieni da Nonna Tua, Vieni!" A commentary on the social construction of grandmothers and its impact on older women's lives. [PDF]

J Frailty Aging
Coelho-Júnior HJ, Calvani R, Marzetti E.   +2 more
europepmc   +1 more source

SOCIAL DIALOGUE MANAGEMENT AT THE COINTERESTED GROUPS’ LEVEL [PDF]

A uniform reglementation of the social dialogue system in Romania, of its functionality and development, in the context of clearly defined responsibilities, can lead to the harmonization of construction, the avoidance of omissions and parallelisms, the ...
Camelia KONRAD
core  

Evaluation of in vitro toxicity of common phytochemicals included in weight loss supplements using 1H NMR spectroscopy

FEBS Open Bio, EarlyView.
We investigated the toxicity of 12 active compounds commonly found in herbal weight loss supplements (WLS) using human liver and colon cell models. Epigallocatechin‐3‐gallate was the only compound showing significant toxicity. Metabolic profiling revealed protein degradation, disrupted energy and lipid metabolism suggesting that the inclusion of EGCG ...
Emily C. Davies, Garth L. Maker, Ian F. Musgrave, Samantha Lodge   +3 more
wiley   +1 more source

Reconstructing the Social Construction of Reality. [PDF]

Br J Sociol
Fraser NM, Turcan RV.
europepmc   +1 more source

Mycobacterial cell division arrest and smooth‐to‐rough envelope transition using CRISPRi‐mediated genetic repression systems

FEBS Open Bio, EarlyView.
CRISPRI‐mediated gene silencing and phenotypic exploration in nontuberculous mycobacteria. In this Research Protocol, we describe approaches to control, monitor, and quantitatively assess CRISPRI‐mediated gene silencing in M. smegmatis and M. abscessus model organisms.
Vanessa Point, Wafaa Achache, Janïs Laudouze, Eliana Sepulveda Ramos, Mickaël Maziero, Céline Crauste, Stéphane Canaan, Pierre Santucci   +7 more
wiley   +1 more source

The social construction of Aduhelm in the context of pharmaceutical ambiguity: exploring narratives from informal caregivers, medical professionals, and redditors on r/Alzheimers. [PDF]

Front Sociol
Simoni Z, Hilfiker V.
europepmc   +1 more source