Results 41 to 50 of about 233,334 (261)

Reciprocal control of viral infection and phosphoinositide dynamics

open access: yesFEBS Letters, EarlyView.
Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley   +1 more source

Obligations as Social Constructs [PDF]

open access: yes, 2003
In this paper we formalize sanction-based obligations in the context of Searle's notion of construction of social reality. In particular, we define obligations using a counts as conditional, Anderson's reduction to alethic modal logic and Boella and Lesmo's normative agent. Our analysis presents an alternative criticism to the weakening rule, which has
BOELLA, Guido, VAN DER TORRE L.
openaire   +2 more sources

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

open access: yesFEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho   +3 more
wiley   +1 more source

Ecosystem and Social Construction: an Interdisciplinary Case Study of the Shurkul Lake Landscape in Khorezm, Uzbekistan.

open access: yesEcology and Society, 2011
Transformation of the Khorezm region of Uzbekistan from forested to agricultural landscapes resulted in the formation of hundreds of lakes, the dynamics of which are largely controlled by inputs from irrigation runoff waters.
Lisa Oberkircher   +3 more
doaj   +1 more source

The role and implications of mammalian cellular circadian entrainment

open access: yesFEBS Letters, EarlyView.
At their most fundamental level, mammalian circadian rhythms occur inside every individual cell. To tell the correct time, cells must align (or ‘entrain’) their circadian rhythm to the external environment. In this review, we highlight how cells entrain to the major circadian cues of light, feeding and temperature, and the implications this has for our
Priya Crosby
wiley   +1 more source

KONSTRUKSI REMAJA PEREMPUAN DI SINETRON

open access: yesJournal Communication Spectrum, 2012
Femininity is a social construction that reproduce the being of woman in dayly life. Being a woman in general is represented by beauty, tall, lean, submissive, kind and thinking more of other people rather that herself. The study shows that being a women
Widjajanti M. Santoso
doaj   +1 more source

Crosstalk between the ribosome quality control‐associated E3 ubiquitin ligases LTN1 and RNF10

open access: yesFEBS Letters, EarlyView.
Loss of the E3 ligase LTN1, the ubiquitin‐like modifier UFM1, or the deubiquitinating enzyme UFSP2 disrupts endoplasmic reticulum–ribosome quality control (ER‐RQC), a pathway that removes stalled ribosomes and faulty proteins. This disruption may trigger a compensatory response to ER‐RQC defects, including increased expression of the E3 ligase RNF10 ...
Yuxi Huang   +8 more
wiley   +1 more source

Natural Kinds, Social Constructions, and Ordinary Language

open access: yesJournal of Social Ontology, 2016
I argue for the importance of clarifying the distinction between metaphysical, semantic, and meta-semantic concerns in the discourse of what Emotion is.
Cecilea Mun
doaj  

Kontruksi Sosial dan Pendidikan Anak dalam Keluarga Pelaku Teroris

open access: yesBidayatuna, 2018
This article discusses the phenomenon of the widespread involvement of children in acts of terrorism in Indonesia, especially those that occurred in 2018. Such phenomenon indicates that mothers and fathers involve their children in acts of terrorism. The
Arini Indah Nihayati
doaj   +1 more source

Function‐driven design of a surrogate interleukin‐2 receptor ligand

open access: yesFEBS Letters, EarlyView.
Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang   +9 more
wiley   +1 more source

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