Results 81 to 90 of about 3,278,528 (360)
Tau acetylation at K331 has limited impact on tau pathology in vivo
FEBS Letters, EarlyView.We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto +3 more
wiley +1 more source
Enhancing the Effectiveness of Social Dialogue Articulation in Europe (EESDA) Project No. VS/2017/0434 Social Dialogue Articulation and Effectiveness: Country Report for France [PDF]
, 2017 This report presents a country study analysing the articulation and effectiveness of social dialogue in France. The methodological approach relies on desk research and semi-structured interviews with social partners in France, aiming at obtaining deeper ...
Akgüç, Mehtap +2 more
core
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
VertigO, 2016 Using a constructivist political ecology perspective, this exploratory qualitative research examines the social representations, attitudes and impacts that exist in relation to the phenomenon of cyanobacteria.
Karine Dubé +3 more
doaj +1 more source
The social construction of age in adult Mexican English language learners : an exploratory study [PDF]
, 2010 This thesis investigates the social construction of age in the context of English\ud foreign language learning in Mexico. Specifically, it looks at how adults of\ud different ages experience learning a new language and how they enact their age\ud ...
Andrew, Patricia Jean
core +1 more source
Occupational safety and health practice: a study at Infrastructure construction work [PDF]
, 2020 Safety is the state of being “safe”, the condition of being protected against physical, social, spiritual, financial, political, emotional, occupational, psychological, educational or other types of consequences of failure, damage, error, accidents, harm
Basharie, Siti Mariam +6 more
core
FEBS Letters, EarlyView.This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel +13 more
wiley +1 more source
Pioneer organization in Samara: from incident to sign
Вестник Самарского университета: История, педагогика, филологияThe article, based on previously unpublished archival sources, examines the process of organizing the first pioneer detachments in Samara, as well as their activities in 1922–1923 using the comparative historical method and microhistorical approach ...
O. A. Titova
doaj +1 more source
New Media & Youth Identity. Issues and Research Pathways [PDF]
, 2015 Media have held a considerable and growing place in the social environment of industrial society in recent decades, transforming the perception that a people have of their place in the world and of their memberships and belonging, creating new paths for
Pattaro, Chiara
core +1 more source
FEBS Letters, EarlyView.Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura +2 more
wiley +1 more source