Results 101 to 110 of about 6,299,984 (299)

Repetitive Negative Thinking outperforms loneliness and lack of social connectedness as a predictor of prospective depressive symptoms in adolescents [PDF]

open access: yesScandinavian Journal of Child and Adolescent Psychiatry and Psychology, 2020
Filip Raes   +5 more
doaj   +1 more source

Tau acetylation at K331 has limited impact on tau pathology in vivo

open access: yesFEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto   +3 more
wiley   +1 more source

The Controlled Social Context" and the Answers of the Social Actors.Two Cases Studies [PDF]

open access: yesRevista Română de Sociologie, 2013
The social context is a system of ideas and beliefs, of norms and habits, also comprising the social and cultural entourage in which the individual evolves and transmits his values by means of education and speech.
ADRIAN NECULAU
doaj  

Economics, Policy, and Organic Agriculture [PDF]

open access: yes, 2009
Is organic agriculture so special that special social theories and methods are needed? The article investigates the question in two steps: First, the article address the question whether agriculture is special.
Ingemann, Jan Holm
core  

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

open access: yesFEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Changes in Funeral Music Practices of Vietnamese People in the Northern Delta, Vietnam

open access: yesHarmonia: Journal of Arts Research and Education
The funeral music of the Vietnamese people in the Northern Delta represents unique type of traditional musical heritage practiced and passed down by many generations of Vietnamese people to this day.
Nguyen Dinh Lam
doaj   +1 more source

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

open access: yesFEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel   +13 more
wiley   +1 more source

The content of the «social literacy» concept in pedagogical theory and practice

open access: yesВестник Майкопского государственного технологического университета
Scientific research in recent years has documented a violation of the mechanism for the inclusion of young citizens in adulthood and the dominance of consumer attitudes among modern youth.
O. E. Sirotkin
doaj   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

open access: yesFEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura   +2 more
wiley   +1 more source

An isoform of 14‐3‐3 protein regulates transbilayer lipid movement at the plasma membrane

open access: yesFEBS Letters, EarlyView.
Loss of 14‐3‐3ζ in CHO cells confers resistance to exogenous phosphatidylserine (PS) and impairs endocytosis‐independent inward flip‐flop of fluorescent PS at the plasma membrane. RNAi‐mediated knockdown reproduces this defect, while no additive effect is seen in ATP11C‐deficient cells.
Akiko Yamaji‐Hasegawa   +3 more
wiley   +1 more source

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