Results 81 to 90 of about 1,435,920 (304)

A Systematic Comparison of Alpha‐Synuclein Seed Amplification Assays for Increasing Reproducibility

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Seed amplification assays (SAAs) enable ultrasensitive detection of misfolded α‐synuclein across biofluids and tissues. Yet, heterogeneity in protocols limits cross‐study comparability and clinical translation. Here, we review α‐synuclein SAA methods and their performance across various biological matrices.
Manuela Amaral‐do‐Nascimento   +3 more
wiley   +1 more source

SOCIAL CONTRACT, CONFLICT AND GAME THEORY

open access: yesRevista Eletrônica do Curso de Direito da UFSM, 2017
The dominant philosophical conception in Western political thought about the emergence of political societies known is the contractualism. Despite this, such conceptions are strongly ahistorical and continue to be strongly criticized by different chains ...
Geziela Iensue, Luis Fernando Sgarbossa
doaj   +1 more source

Locating Rousseau\u27s Legislator in the Social Contract [PDF]

open access: yes, 2011
It is challenging to define precisely what role the legislator plays in Rousseau’s Social Contract; however, when viewed in light of the ancient guardians, the role of the legislator becomes less obscure.
Nussbaumer, Courtney C
core   +1 more source

Constitutions as incomplete social contracts

open access: yesPolitica economica, 2017
Besides sharing a common cultural background, Italy and Spain also share a similar institutional framework. Both are unitary states in the European Union that have devolved responsibilities of mandatory services to be provided nationwide at the sub-national level within rules set at the Constitutional level.
Montolio, D, Turati, G
openaire   +2 more sources

Prognostic Value of Neurofilament Light Chain and Glial Fibrillary Acidic Protein in ALD‐Related Myelopathy

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background X‐linked adrenoleukodystrophy (X‐ALD) is a neurometabolic disorder caused by pathogenic variants in ABCD1, leading to slowly progressive spinal cord disease in nearly all affected men. Sensitive biomarkers to quantify disease severity and predict progression are needed for clinical care and trial design.
Eda G. Kabak   +4 more
wiley   +1 more source

Social organizations and the management contract

open access: yesRevista do Direito Público, 2012
This work aims to show the importance of social organization for social odesenvolvimento . Therefore, this work presents considerations thetrack . Moth general of the Third Sector , highlighting its eorigem concept .
Nina Novaes Coutinho
doaj   +1 more source

LikeStarter: a Smart-contract based Social DAO for Crowdfunding

open access: yes, 2019
Crowdfunding has become a popular form of collective funding, in which small donations or investments, made by groups of people, support the development of new projects in exchange of free products or different types of recognition. Social network sites,
Contu, Michele   +3 more
core   +1 more source

Recurrent Hypothermia and Autonomic Dysfunction Secondary to Shapiro Syndrome

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT A 44‐year‐old man presented with recurrent hypothermia, diaphoresis and hypertension. Extensive investigation for infectious, inflammatory, metabolic and endocrine aetiologies was negative. MR scan of the brain demonstrated no lesions but revealed callosal dysgenesis, consistent with Shapiro syndrome.
Naveen Kumar   +3 more
wiley   +1 more source

Differential Item Functioning on the Patient Health Questionnaire 8 by Disease Subtype, Language, Sex, and Age Among People With Systemic Sclerosis: A Scleroderma Patient‐Centered Intervention Network Cohort Study

open access: yesArthritis Care &Research, EarlyView.
Objective Somatic items used in depression assessments can potentially overlap with symptoms related to physical illness, including systemic sclerosis (SSc). No studies have looked at whether somatic depression items may be influenced by diffuse versus limited SSc disease subtypes, which are associated with varying degrees of symptom presentation.
Sophie Hu   +110 more
wiley   +1 more source

Does Long‐Term Lower Extremity Strength Training in Adults With Knee Osteoarthritis and Varus Alignment Reduce Knee Joint Loading During Gait?

open access: yesArthritis Care &Research, EarlyView.
Objective We examined whether 18 months of strength training in individuals with knee varus alignment and medial tibiofemoral osteoarthritis (OA) reduced knee joint loads during walking compared to an attention control group. Methods This study was a secondary analysis of a randomized clinical trial that compared the effects of strength training to a ...
Stephen P. Messier   +12 more
wiley   +1 more source

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