Results 31 to 40 of about 1,415,295 (314)

(Breaking) the Law: Social Control, Self-Help and Violence in the Tale of Gamelyn

open access: yesStudia Anglica Posnaniensia, 2013
Fourteenth century England experienced social changes which influenced the attitude to crown law and triggered a growing distrust to law and its representatives.
Ludwikowska Joanna
doaj   +1 more source

Corporate totalitarianism: an analysis of Bata system in Brazil and Chile (1940-1970)

open access: yesRevista Mundos do Trabalho, 2020
During the 1930s, the Czech company Bata Shoes Corporation became a well-established multinational organization. It figured amidst the largest shoes producers in the world, being a pioneer in carrying out economic, organizational and social ...
Vinícius de Rezende
doaj   +1 more source

Single‐cell insights into the role of T cells in B‐cell malignancies

open access: yesFEBS Letters, EarlyView.
Single‐cell technologies have transformed our understanding of T cell–tumor cell interactions in B‐cell malignancies, revealing new T‐cell subsets, functional states, and immune evasion mechanisms. This Review synthesizes these findings, highlighting the roles of T cells in pathogenesis, progression, and therapy response, and underscoring their ...
Laura Llaó‐Cid
wiley   +1 more source

The epithelial barrier theory proposes a comprehensive explanation for the origins of allergic and other chronic noncommunicable diseases

open access: yesFEBS Letters, EarlyView.
Exposure to common noxious agents (1), including allergens, pollutants, and micro‐nanoplastics, can cause epithelial barrier damage (2) in our body's protective linings. This may trigger an immune response to our microbiome (3). The epithelial barrier theory explains how this process can lead to chronic noncommunicable diseases (4) affecting organs ...
Can Zeyneloglu   +17 more
wiley   +1 more source

Beyond America's War on Drugs: Developing Public Policy to Navigate the Prevailing Pharmacological Revolution

open access: yesAIMS Public Health, 2015
This paper places America's “war on drugs” in perspective in order to develop a new metaphor for control of drug misuse. A brief and focused history of America's experience with substance use and substance use policy over the past several hundred years ...
Andrew Golub   +2 more
doaj   +1 more source

Goodbye flat lymphoma biology

open access: yesFEBS Letters, EarlyView.
Three‐dimensional (3D) biological systems have become key tools in lymphoma research, offering reliable in vitro and ex vivo platforms to explore pathogenesis and support precision medicine. This review highlights current 3D non‐Hodgkin lymphoma models, detailing their features, advantages, and limitations, and provides a broad perspective on future ...
Carla Faria   +3 more
wiley   +1 more source

From omics to AI—mapping the pathogenic pathways in type 2 diabetes

open access: yesFEBS Letters, EarlyView.
Integrating multi‐omics data with AI‐based modelling (unsupervised and supervised machine learning) identify optimal patient clusters, informing AI‐driven accurate risk stratification. Digital twins simulate individual trajectories in real time, guiding precision medicine by matching patients to targeted therapies.
Siobhán O'Sullivan   +2 more
wiley   +1 more source

Social and Physical Neighbourhood Effects and Crime: Bringing Domains Together Through Collective Efficacy Theory

open access: yesSocial Sciences, 2019
Criminologists and social scientists have long sought to explain why crime rates vary across urban landscapes. By dissecting the city into neighbourhood units, consideration has been given to the comparable features of settings under study which may help
Sam J. Cole
doaj   +1 more source

ERBIN limits epithelial cell plasticity via suppression of TGF‐β signaling

open access: yesFEBS Letters, EarlyView.
In breast and lung cancer patients, low ERBIN expression correlates with poor clinical outcomes. Here, we show that ERBIN inhibits TGF‐β‐induced epithelial‐to‐mesenchymal transition in NMuMG breast and A549 lung adenocarcinoma cell lines. ERBIN suppresses TGF‐β/SMAD signaling and reduces TGF‐β‐induced ERK phosphorylation.
Chao Li   +3 more
wiley   +1 more source

Pratiques et discours de l’altérité négative dans le cadre de la crise Argentine

open access: yesCahiers des Amériques Latines, 2002
In Argentina, the increase in poverty which accompanied the neo-liberal cycle has renewed social tensions affecting political representation. The crisis of December 2001 installed social protest, but it also re-launched another strong, more primitive ...
Edgardo Manero
doaj   +1 more source

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