Results 51 to 60 of about 7,059,412 (353)

Calcium‐sensing receptor‐ and ADAM10‐mediated klotho shedding is regulated by tetraspanin 5

FEBS Letters, Volume 599, Issue 6, Page 866-875, March 2025.
The G protein‐coupled calcium‐sensing receptor (CaSR) and the disintegrin/metalloprotease ADAM10 in the renal distal convoluted tubule control systemic levels of Klotho, a cell and tissue homeostasis‐preserving factor. We show that CaSR‐induced cleavage of membrane‐bound αKlotho by ADAM10 requires tetraspanin 5 (Tspan5), a scaffolding and chaperone ...
Zhenan Liu, Joonho Yoon, Eunyoung Lee, Audrey N. Chang, R. Tyler Miller   +4 more
wiley   +1 more source

ACCESS CONTROL IN A SOCIAL NETWORKING ENVIRONMENT [PDF]

, 2013
Collecting users into groups is a common activity in social networking sites such as Facebook, Google groups, Yahoo groups and many other web applications. This project explores access control techniques for dynamically created groups. The starting point
Perepa, Mallika
core   +1 more source

Human colon organoid differentiation from induced pluripotent stem cells using an improved method

FEBS Letters, Volume 599, Issue 6, Page 912-924, March 2025.
We compared established protocols to differentiate induced pluripotent stem cells into colon organoids and found that activation of bone morphogenetic protein 2 signaling induced gene expression of colon‐specific markers. Adenovirus‐mediated transduction of the transcription factors HOXD13 or SATB2 further enhanced colonic gene expression, suggesting ...
I‐Ting Lee, Yu Takahashi, Takashi Sasaki, Yoshio Yamauchi, Ryuichiro Sato   +4 more
wiley   +1 more source

Methodology in Legal Research

Utrecht Law Review, 2017
Recent legal scholarship demonstrates increased attention to empirical research in the design and evaluation of law and the policies and practices of legal authorities.
Tom R. Tyler
doaj   +1 more source

Stable Community Structures and Social Exclusion [PDF]

arXiv, 2020
In this paper we study social exclusion in social (information) networks using a game-theoretic approach, and study the stability of a certain class community structures that are a Nash equilibrium. The main result of our analysis shows that all stable community structures (Nash equilibria) in this class are community structures under which some agents
arxiv  

Insights into the renal pathophysiology in Hermansky‐Pudlak syndrome‐1 from urinary extracellular vesicle proteomics and a new mouse model

FEBS Letters, Volume 599, Issue 7, Page 1055-1074, April 2025.
Hermansky‐Pudlak syndrome type 1 (HPS‐1) is a rare, autosomal recessive disorder with poorly understood renal involvement. Urinary extracellular vesicle (uEV) proteomics and a novel Hps1 mouse model reveal mitochondrial abnormalities and lipid accumulation in HPS‐1 kidney proximal tubule cells. Serum ApoA1 correlates with kidney function in our patient
Dawn M. Maynard, Bernadette R. Gochuico, Hadass Pri Chen, Christopher K. E. Bleck, Patricia M. Zerfas, Wendy J. Introne, William A. Gahl, May C. V. Malicdan   +7 more
wiley   +1 more source

Contact tracing and epidemics control in social networks

, 2002
A generalization of the standard susceptible-infectious-removed (SIR) stochastic model for epidemics in sparse random networks is introduced which incorporates contact tracing in addition to random screening.
A. Johansen, C. Moore, D. ben-Avraham, D. J. Watts, D. T. Gillespie, J. Müller, J. Müller, J. Müller, Lev S. Tsimring, M. E. J. Newman, R. Albert, R. Pastor-Satorras, Ramon Huerta, S. H. Strogatz   +13 more
core   +1 more source

Residues R177 and S178 of the human Na+/H+ antiporter NHA2 are involved in its inhibition by the flavonoid phloretin

FEBS Letters, Volume 599, Issue 6, Page 901-911, March 2025.
The human Na+/H+ antiporter NHA2 transports Na+ or Li+ in exchange for protons across cell membranes, and its dysfunction results in various pathologies, e.g., fertility disorders, hypertension, or diabetes. This work provides the molecular characterization of interactions of NHA2 with its specific inhibitor phloretin, which can be helpful for the ...
Olga Zimmermannova, Martin Kubeš, Tereza Przeczková, Gal Masrati   +3 more
wiley   +1 more source

Linear quadratic mean field social optimization: Asymptotic solvability and decentralized control [PDF]

arXiv, 2020
This paper studies asymptotic solvability of a linear quadratic (LQ) mean field social optimization problem with controlled diffusions and indefinite state and control weights. Starting with an $N$-agent model, we employ a rescaling approach to derive a low-dimensional Riccati ordinary differential equation (ODE) system, which characterizes a necessary
arxiv  

Evolution of Social Power in Social Networks with Dynamic Topology [PDF]

IEEE Transactions on Automatic Control, 63(11): pp. 3793-3808, November 2018, 2017
The recently proposed DeGroot-Friedkin model describes the dynamical evolution of individual social power in a social network that holds opinion discussions on a sequence of different issues. This paper revisits that model, and uses nonlinear contraction analysis, among other tools, to establish several novel results.
arxiv   +1 more source