Results 101 to 110 of about 1,340,671 (308)

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

open access: yesFEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel   +13 more
wiley   +1 more source

Child protection and the modernised family justice system [PDF]

open access: yes, 2014
This chapter sets out to examine the impending changes in law and practice in the context of child protection and goes on to explore the implications of these changes for the child protection system.
Kaganas, FR
core  

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

open access: yesFEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura   +2 more
wiley   +1 more source

Metafora konseptual sebagai kritik sosial berbentuk tagar politik

open access: yesDiglosia
Political contestation often produces linguistic phenomena that are interesting to study, such as the presence of metaphorical hashtags. This study examines conceptual metaphors in viral political hashtags during the 2024 General Election on social ...
Ranti Alfiani   +1 more
doaj   +1 more source

Social dilemmas and shame-based sanctions: experimental results from rural Zimbabwe [PDF]

open access: yes
Using two economic experiments I investigate how a sample of rural communities in Zimbabwe approach social dilemmas. When provided with an opportunity to impose sanctions in the context of a public goods game, fourteen out of eighteen communities ...
Abigail Barr
core  

An Analysis of Social Politic Elements in Iwan Fals’ Song Collection. Setya Sukma Ludiantari.117010010 [PDF]

open access: yes, 2016
This research is a study of ekstrinsic elements in Iwan Fals songs collection. Iwan Fals famous with songs that contain social and political criticism. The writer feel attracted to discuss Iwan Fals songs collection.
SETYA SUKMA LUDIANTARI
core  

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

open access: yesFEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz   +11 more
wiley   +1 more source

The ubiquitin ligase RNF115 is required for the clearance of damaged lysosomes

open access: yesFEBS Letters, EarlyView.
Upon lysosomal rupture, an E3 ubiquitin ligase RNF115 translocates from the cytosol to the damaged lysosomal membrane. Moreover, RNF115 depletion impairs the clearance of damaged lysosomes, identifying it as a key regulator of lysosomal quality control.
Sae Nakanaga   +3 more
wiley   +1 more source

Organizing the interface—Plasma membrane architecture and receptor dynamics in virus‐cell interactions

open access: yesFEBS Letters, EarlyView.
Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley   +1 more source

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