Results 41 to 50 of about 11,979,165 (254)

Terror no sertão : um encontro entre o fantástico, o humor e a crítica social

open access: yesAmerika, 2023
The sertão has been taken as a space for the development of horror literature since the 19th century, according to Silva (2016), with works such as O Cabeleira (1876), by Franklin Távora and Os brilhantes (1895), by Rodolfo Teófilo.
Laís Maria Rosal Botler
doaj   +1 more source

Organoids in pediatric cancer research

open access: yesFEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

Kırmızı Pazartesi ve Kuyucaklı Yusuf Romanlarının Toplumcu Gerçekçi ve Sosyolojik Eleştiri Bağlamında Karşılaştırmalı Analizi

open access: yesSkad, 2020
Edebiyat her kültür içerisinde şekillenmiş toplumsal yapı ve değerleri doğal olarak yansıtan bir estetik araçtır. Yazarlar kendi toplumlarının içinden çıkan birer fert olarak bu estetik aracı çeşitli nedenlerle kullanarak farklı türlerde eserler verirler.
Ferhan Öztürk
doaj   +1 more source

The planar cell polarity protein Vangl2 interacts with the PDZ‐domains of Scribble but not with a unique PDZ‐like domain in Inturned

open access: yesFEBS Letters, EarlyView.
Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes   +4 more
wiley   +1 more source

Actors and Vehicles of Architectural Criticism (4)

open access: yes, 2016
From Satire to Criticism: Comics in Architecture Publications in the 1960s and 1970s Carlos Machado e Moura Faculdade de Arquitectura da Universidade do Porto Cartoons, in the tradition of the graphic satire, have been an acute form of criticism of ...
Mapping Architectural Criticism
core   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

open access: yesFEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

America’s Barbarian Heart

open access: yesRSA Journal, 2017
The article explores the narrative space, the combined use of various genre tropes, and the social criticism in Dave Eggers’s Heroes of the Frontier (2016).
Virginia Pignagnoli
doaj   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

open access: yesFEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura   +2 more
wiley   +1 more source

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

open access: yesFEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz   +11 more
wiley   +1 more source

Architectural Criticism between Public Debate and Autonomous Discipline (4)

open access: yes, 2016
Fixing boundaries. Architecture and criticism at the onset of the 20th century Rute Figueiredo gta/D-ARCH/ETH Zurich, Director of the Site of Discourse Research Project (Lisbon University) During the last few years, there has been an increasing interest ...
Mapping Architectural Criticism
core   +1 more source

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