Results 121 to 130 of about 1,220,316 (313)
FEBS Letters, EarlyView.We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley +1 more source
Some Varieties of Normative Social Critique
Nordicum-Mediterraneum, 2013 The article distinguishes between different forms of normative social critique: an external, an internal or immanent, and a disclosing form of critique. Whereas the external and internal critique appeal to or rely upon a certain standard or yardstick of ...
Carl-Göran Heidegren
doaj
FEBS Letters, EarlyView.In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai +9 more
wiley +1 more source
Critique éducative, critique institutionnelle et critique sociale
Les cahiers de pédagogies radicales, 2022 openaire +1 more source
FEBS Letters, EarlyView.Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes +4 more
wiley +1 more source
Extending the original position : revisiting the Pattanaik critique of Vickrey/Harsanyi utilitarianism [PDF]
, 2013 Harsanyi's original position treats personal identity, upon which each individual's utility depends, as risky. Pattanaik's critique is related to the problem of scaling "state-dependent" von Neumann-Morgenstern utility when determining subjective ...
Hammond, Peter J.
core +1 more source
Tau acetylation at K331 has limited impact on tau pathology in vivo
FEBS Letters, EarlyView.We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto +3 more
wiley +1 more source
Attributions as Behavior Explanations: Toward a New Theory [PDF]
, 2003 Attribution theory has played a major role in social-psychological research. Unfortunately, the term attribution is ambiguous. According to one meaning, forming an attribution is making a dispositional (trait) inference from behavior; according to ...
Malle, Bertram
core
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
A critique on the application of systems analysis to social problems [PDF]
Systems analysis related to technology utilization and spinoff from aerospace ...
Hoos, I. R.
core +1 more source