Results 161 to 170 of about 302,695 (261)

Social determinants of health, behavioral factors, and incident dementia: a prospective cohort study. [PDF]

Alzheimers Res Ther
Zhang H, Ding C, Xu Y, Hao H, Gong Y, An T, Hu Z, Li Y, Wang X, Jiang S, Hao M, Li X.   +11 more
europepmc   +1 more source

Automated FRAP microscopy for high‐throughput analysis of protein dynamics in chromatin organization and transcription

FEBS Open Bio, EarlyView.
RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz, Bart Geverts, Johan A. Slotman, Andrea Sacchetti, Stefan Prekovic, Martin E. van Royen, Adriaan B. Houtsmuller   +6 more
wiley   +1 more source

Revisiting the social determinants of health with explainable AI: a cross-country perspective. [PDF]

Am J Epidemiol
Yan J.
europepmc   +1 more source

Mycobacterial cell division arrest and smooth‐to‐rough envelope transition using CRISPRi‐mediated genetic repression systems

FEBS Open Bio, EarlyView.
CRISPRI‐mediated gene silencing and phenotypic exploration in nontuberculous mycobacteria. In this Research Protocol, we describe approaches to control, monitor, and quantitatively assess CRISPRI‐mediated gene silencing in M. smegmatis and M. abscessus model organisms.
Vanessa Point, Wafaa Achache, Janïs Laudouze, Eliana Sepulveda Ramos, Mickaël Maziero, Céline Crauste, Stéphane Canaan, Pierre Santucci   +7 more
wiley   +1 more source

C2α‐carbanion‐protonating glutamate discloses tradeoffs between substrate accommodation and reaction rate in actinobacterial 2‐hydroxyacyl‐CoA lyase

FEBS Open Bio, EarlyView.
Enzymes of the 2‐hydroxyacyl‐CoA lyase group catalyze the condensation of formyl‐CoA with aldehydes or ketones. Thus, by structural adaptation of active sites, practically any pharmaceutically and industrially important 2‐hydroxyacid could be biotechnologically synthesized. Combining crystal structure analysis, active site mutations and kinetic assays,
Michael Zahn, Barbara Seroka, Ryszard Lazny, Zenon Lotowski, Thore Rohwerder   +4 more
wiley   +1 more source

Social Determinants of Health and Clinical Outcomes in Hypertrophic Cardiomyopathy.

JAMA Cardiol
Hafeez N, Claggett BL, Owens AT, Helms AS, Saberi S, Lampert R, Stendahl JC, Ashley EA, Parikh VN, Lakdawala NK, Ingles J, Olivotto I, Ho CY, Taylor MR, Khan SS, Day SM.   +15 more
europepmc   +1 more source

Advancing Mental Health Equity in Epilepsy: Social Determinants of Health Across the Lifespan. [PDF]

Epilepsy Curr
Gopaul M, Fox J, Smith AW, Maturu S, McInnis R, Patel PS, Brothers S, Duberstein S, Woodward J, Conner K, Beimer N, Strom L, Wojnaroski M, Munger-Clary H.   +13 more
europepmc   +1 more source

A light‐triggered Time‐Resolved X‐ray Solution Scattering (TR‐XSS) workflow with application to protein conformational dynamics

FEBS Open Bio, EarlyView.
Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei, Fredrik Orädd, Konstantinos Magkakis, Magnus Andersson   +3 more
wiley   +1 more source