Results 251 to 260 of about 3,761,638 (421)

Disadvantage, Risk and the Social Determinants of Health [PDF]

, 2009
Jonathan Wolff
openalex   +1 more source

Targeting the MDM2‐MDM4 interaction interface reveals an otherwise therapeutically active wild‐type p53 in colorectal cancer

Molecular Oncology, EarlyView.
This study investigates an alternative approach to reactivating the oncosuppressor p53 in cancer. A short peptide targeting the association of the two p53 inhibitors, MDM2 and MDM4, induces an otherwise therapeutically active p53 with unique features that promote cell death and potentially reduce toxicity towards proliferating nontumor cells.
Sonia Valentini, Giada Mele, Marika Attili, Maria Rita Assenza, Fulvio Saccoccia, Francesca Sardina, Cinzia Rinaldo, Roberto Massari, Nicola Tirelli, Alfredo Pontecorvi, Fabiola Moretti   +10 more
wiley   +1 more source

People's health and the social determinants of health [PDF]

Health Promotion Journal of Australia, 2018
openaire   +3 more sources

The social determinants of child health: variations across health outcomes – a population-based cross-sectional analysis [PDF]

, 2009
Charlemaigne Victorino, Anne H. Gauthier
openalex   +1 more source

Highly multiplexed digital PCR assay for simultaneous quantification of variant allele frequencies and copy number alterations of KRAS and GNAS in pancreatic cancer precursors

Molecular Oncology, EarlyView.
Combining melting curve analysis enhances the multiplexing capability of digital PCR. Here, we developed a 14‐plex assay to simultaneously measure single nucleotide mutations and amplifications of KRAS and GNAS, which are common driver genes in pancreatic cancer precursors. This assay accurately quantified variant allele frequencies in clinical samples
Junko Tanaka, Tatsuo Nakagawa, Yusuke Ono, Yoshio Kamura, Takeshi Ishida, Hidemasa Kawabata, Kenji Takahashi, Hiroki Sato, Andrew S. Liss, Yusuke Mizukami, Takahide Yokoi   +10 more
wiley   +1 more source

Large language models for identifying social determinants of health. [PDF]

Proc Natl Acad Sci U S A
Wang Y.
europepmc   +1 more source

Evaluation of community level interventions to address social and structural determinants of health: a cluster randomised controlled trial [PDF]

, 2009
Martin Wall, Richard Hayes, David G. Moore, Mark Petticrew, Angela Clow, Elena Schmidt, Alizon Draper, Karen Lock, Rebecca Lynch, Adrian Renton   +9 more
openalex   +1 more source

Rhode Island’s Health Equity Zones: Addressing Local Problems with Local Solutions

, 2017
The Rhode Island Department of Health (RIDOH) describes the strategies and infrastructure it has developed to fund its placed-based initiatives to address the social determinants of health to eliminate health disparities.
Alexander-Scott, MD, MPH, Nicole, Ankoma, MPH, MSW, Angela B., Fulton, PhD, John P., Hall-Walker, MPA, Carol, Novais, MA, Ana P.   +4 more
core  

Exploration of heterogeneity and recurrence signatures in hepatocellular carcinoma

Molecular Oncology, EarlyView.
This study leveraged public datasets and integrative bioinformatic analysis to dissect malignant cell heterogeneity between relapsed and primary HCC, focusing on intercellular communication, differentiation status, metabolic activity, and transcriptomic profiles.
Wen‐Jing Wu, Jianchao Wang, Fuqing Chen, Xuefeng Wang, Bin Lan, Ruyi Fu, Hong Wen, Fangfang Chen, Wei Hong, Tian‐Yu Tang, Ying He, Gang Chen, Jianyin Zhou, Hai‐Long Piao, Di Chen, Shu‐Yong Lin   +15 more
wiley   +1 more source

A communicative model of premenstrual syndrome with social determinants of health: a path analysis. [PDF]

BMC Womens Health
Vakili F, Nasiri M, Jahanfar S, Alamolhoda SH, Hamzehgardeshi Z, Salehi F, Fini MH.   +6 more
europepmc   +1 more source