Results 121 to 130 of about 391,486 (306)

The Time Value of Carbon and Carbon Storage: Clarifying the terms and the policy implications of the debate [PDF]

The question of whether there is any value to the temporary storage of carbon is fundamental to climate policy design across a number of arenas, including physical carbon discounting in greenhouse gas accounting, the relative value of temporary carbon ...
Kelly, Alexia, Marshall, Liz
core   +1 more source

Risk-adjusted social discount rates

, 2020
When evaluating public and private investment projects, those that contribute more to the collective risk should be more penalized through an upward adjustment of their discount rate. This paper shows how to estimate the risk-adjusted discount rate for different projects, with applications to the electricity sector.
Cherbonnier, Frédéric, Gollier, Christian   +1 more
openaire   +2 more sources

Spatiotemporal Sequential Delivery of Chidamide Regulates Macrophage Reprogramming in Lymphoma Microenvironment Through HDACs‐STAT3 Pathway

Advanced Science, EarlyView.
Our study identifies the HDACs‐STAT3 axis as key regulator for M2 macrophage accumulation in DLBCL. We developed Chid@M2pep‐EVs/TP, a pH‐responsive drug delivery system for M2 macrophage specific chidamide administration. By coupling M2‐targeted chidamide with EVs‐mediated delivery, this system reprograms M2 to M1 via HDAC inhibition and STAT3 ...
Bo Dai, Shuo Wang, Xiaotong Peng, Kunpeng Wu, Mengyao Wu, Zhaoning Lu, Haoshu Zhong, Xiaohan Qian, Shuiyi Tan, Hui Yang, Tanlezi Sun, Jing Wang, Jie Zhang, Hua Jiang, Yin Tong, Tong Chen   +15 more
wiley   +1 more source

Green Energy Markets: Towards an Internal Rate of Return and ESG Factors

Energies
The contemporary green transformation of the economy is a strategic imperative for businesses, especially small and medium-sized enterprises (SMEs) operating in the energy market, forcing the integration of sustainable practices in decision-making ...
Zbysław Dobrowolski, Paweł Dziekański, Grzegorz Drozdowski, Izabella Kęsy, Oleksandr Novoseletskyy, Arkadiusz Babczuk   +5 more
doaj   +1 more source

Consensus Formation and Change are Enhanced by Neutrality

Advanced Science, EarlyView.
Neutral agents are shown to enhance both the formation and overturning of consensus in collective decision‐making. A general mathematical model and experiments with locusts and humans reveal that neutrality enables robust consensus via simple interactions and accelerates consensus change by reducing effective population size.
Andrei Sontag, Janina A. Hoffmann, Tim Rogers, Christian A. Yates   +3 more
wiley   +1 more source

A Central Somatic Transmission Mediates Proprioceptive Facilitation of Muscle Pain

Advanced Science, EarlyView.
Zhang et al. uncover a novel central mechanism for persistent muscle pain, in which TRPA1 sensitization in MeV proprioceptive neurons enhances somatic secretion. This, in turn, disinhibits descending pain control from neighboring noradrenergic locus coeruleus neurons via local GABAergic circuits, thereby promoting inflammatory muscle pain.
Xiaoyu Zhang, Jiale Yang, Xi Wu, Jie Li, Fujian Lu, Yiman Li, Xingyu Du, Rong Huang, Jamila Asgar, Jing Wang, Ke Ren, Feipeng Zhu, Changhe Wang, Yehua Gan, Feng Wei, Zhuan Zhou   +15 more
wiley   +1 more source

Neuid: A Novel Neuron‐Enriched LncRNA that Connects Epigenetic Gene Silencing to Alzheimer's Disease

Advanced Science, EarlyView.
ABSTRACT The increasing evidence that non‐coding RNAs can become deregulated during pathogenesis is dramatically expanding the space for drug discovery beyond the protein‐coding genome. Long noncoding RNAs (lncRNAs) are emerging as key regulators of cellular function, yet most remain uncharacterized.
Ranjit Pradhan, Zorica Petrovic, M. Sadman Sakib, Sophie Schröder, Dennis Manfred Krüger, Tonatiuh Pena, Eren Diniz, Susanne Burkhardt, Anna‐Lena Schütz, Verena Gisa, Iga Grzadzielewska, Karl Toischer, Thor D. Stein, Jan Krzysztof Blusztajn, Ivana Delalle, Jelena Radulovic, Farahnaz Sananbenesi, Andre Fischer   +17 more
wiley   +1 more source

The Equivalency Principle for Discounting the Value of Natural Assets: An Application to an Investment Project in the Basque Coast [PDF]

Making decisions about optimal investments in green infrastructure necessitates setting social discount rates. This paper suggests a practical way for determining the discount rate for projects or programmes in which one of the options is to maintain or ...
Aline Chiabai, Anil Markandya, Ibon Galarraga, Unai Pascual   +3 more
core   +1 more source

On the Origins of Toughness in Corymbia calophylla (Marri Tree) Nuts

Advanced Science, EarlyView.
We uncover the natural toughening mechanisms of the marri nut, including fiber pullout, crack deflection, and a viscoelastic matrix, which enable exceptional energy absorption and ductility comparable to Teflon, with an elastic modulus similar to acrylic.
Wegood M. Awad, Ahmed S. Dalaq, Marieh B. Al‐Handawi, Rezo Getsadze, Oraib Al‐Ketan, James Weston, Mohammed Daqaq, Panče Naumov   +7 more
wiley   +1 more source

A Dynamic Model of Mesh Size Regulatory Compliance [PDF]

This paper employs a dynamic model for crimes that involve time and punishment to analyze the use of a net with illegal mesh size in a management regime where each community claims territorial use right over a fishery but has a discount rate that may ...
Akpalu, Wisdom
core   +1 more source