Results 71 to 80 of about 417,522 (276)
FEBS Letters, EarlyView.This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel +13 more
wiley +1 more source
Social Distancing as p-Dispersion Problem
IEEE Access, 2020 The spread of COVID-19 and similar viruses poses new challenges for our society. There is a strong incentive towards safety measures that help to mitigate the outbreaks.
Jakub Kudela
doaj +1 more source
Diversity and complexity in neural organoids
FEBS Letters, EarlyView.Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley +1 more source
The Biopolitics of Social Distancing
Social Media + Society, 2020 As COVID-19 spreads across the globe, new technologies are being leveraged to enforce social distancing requirements. I explore social distancing through the theoretical lens of Michel Foucault’s biopolitics, with an emphasis on recognizing unauthorized ...
J.J. Sylvia
doaj +1 more source
Forgiving as emotional distancing [PDF]
, 2019 :In this essay, I present an account of forgiveness as a process of emotional distancing. The central claim is that, understood in these terms, forgiveness does not require a change in judgment.
Amaya, Santiago
core
AAA+ protein unfoldases—the Moirai of the proteome
FEBS Letters, EarlyView.AAA+ unfoldases are essential molecular motors that power protein degradation and disaggregation. This review integrates recent cryo‐electron microscopy (cryo‐EM) structures and single‐molecule biophysical data to reconcile competing models of substrate translocation.
Stavros Azinas, Marta Carroni
wiley +1 more source
PLoS ONESocial isolation and disconnectedness increase the risk of worse mental health, which might suggest that preventive health measures (i.e., self-quarantining, social distancing) negatively affect mental health.
Jerin Lee +3 more
doaj +1 more source
The Spread of Social Distancing
SSRN Electronic Journal, 2020 We find that social distancing is affected by the policies set in neighboring counties, even after controlling for confirmed COVID cases and weather. A stay-at-home order in a neighboring county reduces social distancing by more than half as much as implementing an order in that county.
Cook, Jonathan +2 more
openaire +2 more sources
Molecular Oncology, EarlyView.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source
U.S. county level analysis to determine If social distancing slowed the spread of COVID-19
Revista Panamericana de Salud Pública, 2020 Objective. To analyze the effectiveness of social distancing in the United States (U.S.). Methods. A novel cell-phone ping data was used to quantify the measures of social distancing by all U.S. counties. Results.
Tannista Banerjee, Arnab Nayak
doaj +1 more source