Results 51 to 60 of about 403,673 (309)

Understanding safety-critical interactions with a home medical device through Distributed Cognition [PDF]

open access: yes, 2015
As healthcare shifts from the hospital to the home, it is becoming increasingly important to understand how patients interact with home medical devices, to inform the safe and patient-friendly design of these devices.
Blandford, AE, Mayer, A, Rajkomar, A
core  

In vitro models of cancer‐associated fibroblast heterogeneity uncover subtype‐specific effects of CRISPR perturbations

open access: yesMolecular Oncology, EarlyView.
Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra   +10 more
wiley   +1 more source

Heterogeneous distributed problem-solving involving visual objects as boundary objects

open access: yesFrontiers in Communication
Communication involving visualizations in science and applications involves or even requires coordination. Much visualization research focuses on tasks in research or applications and provides valuable insights that help improve these modes and means of ...
Francis Harvey, Francis Harvey
doaj   +1 more source

Beyond mechanistic interaction: Value-based constraints on meaning in language

open access: yesFrontiers in Psychology, 2015
According to situated, embodied, distributed approaches to cognition, language is a crucial means for structuring social interactions. Recent approaches that emphasize the coordinative function of language treat language as a system of replicable ...
Joanna eRączaszek-Leonardi   +1 more
doaj   +1 more source

Engineering affect: emotion regulation, the internet, and the techno-social niche [PDF]

open access: yes, 2019
Philosophical work exploring the relation between cognition and the Internet is now an active area of research. Some adopt an externalist framework, arguing that the Internet should be seen as environmental scaffolding that drives and shapes cognition ...
Krueger, Joel, Osler, Lucy
core  

Infrared laser sampling of low volumes combined with shotgun lipidomics reveals lipid markers in palatine tonsil carcinoma

open access: yesMolecular Oncology, EarlyView.
Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff   +11 more
wiley   +1 more source

Temporalités distribuées et partagées. Une approche écologique des activités familiales dans le foyer

open access: yesTracés, 2012
Temporality is a concern in and a primary fabric of everyday social life. Through multimodal analysis of adult-children interactions, the article explores temporality in the daily lives of a few families within their domestic ...
Natalia La Valle
doaj   +1 more source

Crucial parameters for precise copy number variation detection in formalin‐fixed paraffin‐embedded solid cancer samples

open access: yesMolecular Oncology, EarlyView.
This study shows that copy number variations (CNVs) can be reliably detected in formalin‐fixed paraffin‐embedded (FFPE) solid cancer samples using ultra‐low‐pass whole‐genome sequencing, provided that key (pre)‐analytical parameters are optimized.
Hanne Goris   +10 more
wiley   +1 more source

Correlation of the differential expression of PIK3R1 and its spliced variant, p55α, in pan‐cancer

open access: yesMolecular Oncology, EarlyView.
PIK3R1 undergoes alternative splicing to generate the isoforms, p85α and p55α. By combining large patient datasets with laboratory experiments, we show that PIK3R1 spliced variants shape cancer behavior. While tumors lose the protective p85α isoform, p55α is overexpressed, changes linked to poorer survival and more pronounced in African American ...
Ishita Gupta   +10 more
wiley   +1 more source

Distributed Neural Activity Patterns during Human-to-Human Competition

open access: yesFrontiers in Human Neuroscience, 2017
Interpersonal interaction is the essence of human social behavior. However, conventional neuroimaging techniques have tended to focus on social cognition in single individuals rather than on dyads or groups.
Matthew Piva   +10 more
doaj   +1 more source

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