Results 121 to 130 of about 8,679,260 (339)

C2α‐carbanion‐protonating glutamate discloses tradeoffs between substrate accommodation and reaction rate in actinobacterial 2‐hydroxyacyl‐CoA lyase

open access: yesFEBS Open Bio, EarlyView.
Enzymes of the 2‐hydroxyacyl‐CoA lyase group catalyze the condensation of formyl‐CoA with aldehydes or ketones. Thus, by structural adaptation of active sites, practically any pharmaceutically and industrially important 2‐hydroxyacid could be biotechnologically synthesized. Combining crystal structure analysis, active site mutations and kinetic assays,
Michael Zahn   +4 more
wiley   +1 more source

A light‐triggered Time‐Resolved X‐ray Solution Scattering (TR‐XSS) workflow with application to protein conformational dynamics

open access: yesFEBS Open Bio, EarlyView.
Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei   +3 more
wiley   +1 more source

Sentimentos em relação à política à luz dos valores e do preconceito social

open access: yesOpinião Pública, 2009
Este estudo tem como objetivo analisar os efeitos dos valores e do preconceito social nas atitudes políticas a partir de uma perspectiva psicossociológica. Os valores são estudados em função de quatro indicadores: valores materialistas, pós-materialistas,
Sheyla Christine Santos Fernandes
doaj   +1 more source

Measuring Inequality Without the Pigou-Dalton Condition [PDF]

open access: yes
income differentials, deprivation, satifaction, Lorenz dominance, progressive transfers, expected utility, generalized Gini ...
Chateauneuf, Alain, Moyes, Patrick
core  

Identification of functional murine mitochondrial formyl peptides and their effects on myeloid‐derived suppressor cell generation

open access: yesFEBS Open Bio, EarlyView.
We first identified functional murine mitochondrial N‐formyl peptides (MT‐FPs) and investigated their effects on the in vitro myeloid‐derived suppressor cell (MDSC) generation from bone marrow cells. We demonstrated that MT‐FPs acted directly on bone marrow cells to promote MDSC generation and modulated the polymorphonuclear (PMN)‐MDSC/monocyte (M ...
Miyako Ozawa   +2 more
wiley   +1 more source

Evaluation of social behavior in the Blanco Orejinegro nucleus at UFPSO

open access: yesRevista Ingenio, 2016
Analyzing the livestock inventory that our country has, it can be said that we have great potential with the presence of creole breeds, which for more than 500 years have adapted to the harsh conditions imposed by the tropical environment.
Cesar Augusto Uron Castro
doaj   +1 more source

Analysing the significance of small conformational changes and low occupancy states in serial crystallographic data

open access: yesFEBS Open Bio, EarlyView.
This protocol paper outlines methods to establish the success of a time‐resolved serial crystallographic experiment, by means of statistical analysis of timepoint data in reciprocal space and models in real space. We show how to amplify the signal from excited states to visualise structural changes in successful experiments.
Jake Hill   +4 more
wiley   +1 more source

Social Welfare Analysis of Income Distributions: Ranking Income Distributions with Lorenz Curves [PDF]

open access: yes
This paper illustrates how Lorenz Curves can be used to identify the best income distribution on social welfare grounds, within a set of alternative income distributions generated by different policy options.
Bellù, Lorenzo Giovanni   +1 more
core   +1 more source

Screening and epitope characterization of Nidogen‐2‐specific nanobodies

open access: yesFEBS Open Bio, EarlyView.
Camel immunization and phage display were employed to generate high‐affinity VHH nanobodies against Nidogen‐2. After library construction, biopanning, ELISA screening, sequencing, and recombinant expression, selected nanobodies were purified and characterized, leading to the preliminary exploration of a nanobody‐based sandwich ELISA for specific ...
Jianchuan Wen   +9 more
wiley   +1 more source

Equality of opportunity: Definitions and testable conditions, with an application to income in France [PDF]

open access: yes
We offer a model of equality of opportunity that encompasses different conceptions expressed in the public debate. In addition to circumstances whose effect on outcome should be compensated and eort which represents a legitimate source of inequality, we ...
Alain Trannoy   +2 more
core   +3 more sources

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