Results 121 to 130 of about 655,003 (315)

Acute caffeine treatment protects the developing retina from ischemia‐induced cell death

FEBS Open Bio, EarlyView.
Caffeine reduces cell death in the developing retina under ischemia (OGD). This effect does not involve BDNF upregulation or antioxidant pathways (NRF2/VEGF). Neuroprotection occurs mainly through adenosine A2A receptor antagonism, decreasing glutamate release and excitotoxicity, highlighting caffeine's potential as an acute neuroprotective agent in ...
Amanda Alves Nascimento, Danniel Pereira‐Figueiredo, Gabriella Grossi de Lima Dias, Gabriel Ferreira dos Santos, Mariana Rodrigues Pereira, Rafael Brito, Karin C Calaza   +6 more
wiley   +1 more source

Pharmacological inhibition of the PERK pathway modulates hepatocellular carcinoma growth and immune signaling

FEBS Open Bio, EarlyView.
Pharmacological inhibition of PERK in a DEN‐induced mouse model of liver cancer does not reduce tumor burden but alters cellular stress signaling. Despite blocking PERK activity, downstream stress responses, including CHOP expression, remain active, suggesting compensatory mechanisms within the unfolded protein response that may influence tumor ...
Ada Lerma‐Clavero, Maria Kopsida, Nathalie Arendt, Hans Lennernäs, Markus Sjöblom, Femke Heindryckx   +5 more
wiley   +1 more source

Pathways and pitfalls: a qualitative study of student experiences in biomedical science education

FEBS Open Bio, EarlyView.
Biomedical science students from underrepresented backgrounds face barriers including financial strain, disrupted laboratory access and cultural exclusion. Peer networks provide vital support when institutional systems are difficult to navigate. To create inclusive learning environments and achieve academic success, educators should blend active, hands‐
Olivia J. Russell, Cassy Ross, Panagiota S. Filippou, Bruno Silvester Lopes, Dominic Gilchrist, Paul Dean, Kamar Ameen‐Ali, Tora K. Smulders‐Srinivasan, Ahmad A. Khundakar   +8 more
wiley   +1 more source

Social Engagement, Political Emotions, and Social Change

The main aim of the text is to address the formation of collective affective experiences in the time of crisis, which may or may not lead to social change. I would argue that during social crises there is the potential for the formation of (ephemeral)
Cvejić, Igor
core  

Firm innovations from voluntary dyadic engagement with nonprofit organisations: an exploratory UK study [PDF]

, 2010
This dissertation presents the findings of an exploratory collective case-study examining corporate innovations arising from voluntary dyadic engagement between UK firms and nonprofit organisations (NPOs) focused on social issues.
Holmes, Sara
core  

Customer engagement and co-created value in social media

, 2019
Purpose: The purpose of this paper is to understand the relationship between customer participation, co-created value and customer engagement as well as customer motivation involved in this process.
Thaichon, Park, Quach, Sara, Thaichon, P, Shao, W, Shao, Wei, Ross, Mitchell, Quach, S, Ross, M   +7 more
core   +1 more source

Aging Is a Key Driver for Adult Acute Myeloid Leukemia

Aging and Cancer, EarlyView.
Acute myeloid leukemia (AML) is a classical age‐related hematologic malignancy, and a key driver of AML is aging, which profoundly regulates intrinsic factors such as genomic instability, epigenetic reprogramming, and metabolic dysregulation, and alters bone marrow microenvironment.
Rong Yin, Haojian Zhang
wiley   +1 more source

Participation in Healthy Ageing Centres in Bosnia and Herzegovina Is Associated with Increased Physical Activity, Social Interactions, and Life Satisfaction Among Older People: A Cross-Sectional Study

Journal of Ageing and Longevity
Background: The global population is experiencing a demographic shift towards older ages, which has the potential to increase the prevalence of ageing-related diseases and associated healthcare costs. Promoting healthy ageing behaviours, such as physical
Daniela Pamias-Lopez, Tara Keck
doaj   +1 more source

Strength in Numbers: How Social Resources Travel Together to Increase Employee Engagement [PDF]

Based on a 2021 survey of 273 Australian workers across a range of occupations and industries, our structural equation modelling showed that workplace inclusion is a key driver of social resources for building employee engagement within the organisation.
Southey, Kim, Sands, John, Murray, Peter A., Gibson, Marnie, Ong, Derek   +4 more
core   +1 more source

Mutant NPM1 in Acute Myeloid Leukemia Initiation and Maintenance

Aging and Cancer, EarlyView.
NPM1 mutations drive acute myeloid leukemia by acting as neomorphic transcriptional regulators that cooperate with Menin–MLL and XPO1 to sustain HOX/MEIS1 expression and block differentiation. Targeting these mutant‐specific transcriptional dependencies provides a rational therapeutic strategy for NPM1‐mutated AML.
Yanan Jiang, Zhong Fan, Runmeng Liu, Xiaotian Zhang   +3 more
wiley   +1 more source