Results 91 to 100 of about 2,209,260 (308)
Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells
Molecular Oncology, EarlyView.Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son +13 more
wiley +1 more source
Climate Catastrophe and Stanley Milgram’s Electric Shock “Obedience” Experiments: An Uncanny Analogy
Social Sciences, 2019 Awareness of impending climate catastrophe has greatly increased over the last 30 years. Increasing awareness, however, has not translated into decreasing but instead increasing greenhouse gas emissions.
Nestar Russell, Annette Bolton
doaj +1 more source
Education in values in engineering. Energy for human development and sustainability [PDF]
, 2008 nergy is central to achieving th e interrelated econo mic, social, and environmental aims of sustaina ble human development. This pa per relates some UPC efforts to introduce the sustainable energy concept in its engineering curricula.
Velo García, Enrique
core
Molecular Oncology, EarlyView.We developed and validated a DNA methylation–based biomarker panel to distinguish pleural mesothelioma from other pleural conditions. Using the IMPRESS technology, we translated this panel into a clinically applicable assay. The resulting two classifier models demonstrated excellent performance, achieving high AUC values and strong diagnostic accuracy.
Janah Vandenhoeck +12 more
wiley +1 more source
Molecular Oncology, EarlyView.Liquid biopsy enables minimally invasive, real‐time molecular profiling through analysis of circulating biomarkers in biological fluids. This Perspective highlights the importance of training pathologists through integrative educational programs, such as the European Masters in Molecular Pathology, to ensure effective and equitable implementation of ...
Marius Ilié +13 more
wiley +1 more source
Social Engineering Attacks During the COVID-19 Pandemic. [PDF]
SN Comput Sci, 2021 Venkatesha S, Reddy KR, Chandavarkar BR.
europepmc +1 more source
Next‐generation proteomics improves lung cancer risk prediction
Molecular Oncology, EarlyView.This is one of very few studies that used prediagnostic blood samples from participants of two large population‐based cohorts. We identified, evaluated, and validated an innovative protein marker model that outperformed an established risk prediction model and criteria employed by low‐dose computed tomography in lung cancer screening trials.
Megha Bhardwaj +4 more
wiley +1 more source
Correction to: Social Engineering Attacks During the COVID-19 Pandemic. [PDF]
SN Comput Sci, 2021 Venkatesha S, Reddy KR, Chandavarkar BR.
europepmc +1 more source
Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells
Molecular Oncology, EarlyView.We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller +17 more
wiley +1 more source
Applied SciencesPhishing emails are malicious email messages that aim to deceive users into revealing sensitive information by imitating legitimate emails. These emails are usually among the first steps in most cyberattacks, often appearing as an urgent message ...
Alexandros Kavvadias +1 more
doaj +1 more source