Results 71 to 80 of about 318,491 (290)

Evaluation of in vitro toxicity of common phytochemicals included in weight loss supplements using 1H NMR spectroscopy

open access: yesFEBS Open Bio, EarlyView.
We investigated the toxicity of 12 active compounds commonly found in herbal weight loss supplements (WLS) using human liver and colon cell models. Epigallocatechin‐3‐gallate was the only compound showing significant toxicity. Metabolic profiling revealed protein degradation, disrupted energy and lipid metabolism suggesting that the inclusion of EGCG ...
Emily C. Davies   +3 more
wiley   +1 more source

AI-Powered Social Engineering: Emerging Attack Vectors, Vulnerabilities, and Multi-Layered Defense Strategies

open access: yesComputers
In the past decade, a growing number of cyberattacks have been reported, enabling unprecedented levels of personalization, automation, and deception. For instance, recent industry surveys have reported sharp increases in unique social engineering attacks
Kely Gonzaga   +3 more
doaj   +1 more source

dUTPase is essential in zebrafish development and possesses several single‐nucleotide variants with pronounced structural and functional consequences

open access: yesFEBS Open Bio, EarlyView.
dUTPases are involved in balancing the appropriate nucleotide pools. We showed that dUTPase is essential for normal development in zebrafish. The different zebrafish genomes contain several single‐nucleotide variations (SNPs) of the dut gene. One of the dUTPase variants displayed drastically lower protein stability and catalytic efficiency as compared ...
Viktória Perey‐Simon   +6 more
wiley   +1 more source

Dapagliflozin prevents methylglyoxal‐induced retinal cell death in ARPE‐19 cells

open access: yesFEBS Open Bio, EarlyView.
Diabetic macular oedema is a diabetes complication of the eye, which may lead to permanent blindness. ARPE‐19 are human retinal cells used to study retinal diseases and potential therapeutics. Methylglyoxal is a compound increased in uncontrolled diabetes due to elevated blood glucose.
Naina Trivedi   +7 more
wiley   +1 more source

Synthetic Social Engineering Scenario Generation Using LLMs for Awareness-Based Attack Resilience

open access: yesIEEE Access
Social engineering is found in a strong majority of cyberattacks today, as it is a powerful manipulation tactic that does not require the technical skills of hacking.
Jade Webb, Faranak Abri, Sayma Akther
doaj   +1 more source

On the influence of topological characteristics on robustness of complex networks

open access: yes, 2013
In this paper, we explore the relationship between the topological characteristics of a complex network and its robustness to sustained targeted attacks.
Kasthurirathna, Dharshana   +2 more
core   +1 more source

Social Engineering Attacks in Cybersecurity

open access: yesInternational Journal for Research in Applied Science and Engineering Technology
Abstract: In recent years, social engineering has become one of the most insidious forms of cyber attack, exploiting human vulnerabilities rather than technical flaws. This paper aims to dissect the landscape of social engineering attacks, especially in the context of recent developments during 2024 and 2025.
Dr. S. Gomathi Alias Rohini   +2 more
openaire   +1 more source

On the anatomy of social engineering attacks—A literature‐based dissection of successful attacks [PDF]

open access: yesJournal of Investigative Psychology and Offender Profiling, 2017
AbstractThe aim of this study was to explore the extent to which persuasion principles are used in successful social engineering attacks. Seventy‐four scenarios were extracted from 4 books on social engineering (written by social engineers) and analysed.
Bullée, Jan Willem Hendrik (author)   +4 more
openaire   +4 more sources

Dihydroorotate dehydrogenase (DHODH) regulates trophoblast syncytialization through organelle stress–induced cellular senescence

open access: yesFEBS Open Bio, EarlyView.
The inhibition of mitochondrial dihydroorotate dehydrogenase (DHODH) impairs syncytialization and induces cellular senescence via mitochondrial and endoplasmic reticulum stress in human trophoblast stem cells, elevating sFlt1/PlGF levels, a hallmark of placental dysfunction in hypertensive disorders of pregnancy.
Kanoko Yoshida   +6 more
wiley   +1 more source

C2α‐carbanion‐protonating glutamate discloses tradeoffs between substrate accommodation and reaction rate in actinobacterial 2‐hydroxyacyl‐CoA lyase

open access: yesFEBS Open Bio, EarlyView.
Enzymes of the 2‐hydroxyacyl‐CoA lyase group catalyze the condensation of formyl‐CoA with aldehydes or ketones. Thus, by structural adaptation of active sites, practically any pharmaceutically and industrially important 2‐hydroxyacid could be biotechnologically synthesized. Combining crystal structure analysis, active site mutations and kinetic assays,
Michael Zahn   +4 more
wiley   +1 more source

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