Results 101 to 110 of about 1,205,744 (276)

Molecular Appendix Adjusted Architectural Propagations of Red‐Light Controlled Macroscopic Photoactuating Performances

open access: yesAdvanced Robotics Research, EarlyView.
Amphiphilic chloroazobenzenes, bearing different amino acids as end groups alanine, phenylalanine, and valine, exhibit excellent photoisomerizations. Varying structures of three amino acid groups participate in supramolecular formations and therefore photoinduced morphological transformations via adjusting intermolecular interactions. These interaction
Shuangshuang Meng   +3 more
wiley   +1 more source

Targeting UXS1‐Dependent Glucuronate Detoxification Potentiates Metformin's Anti‐Tumor Efficacy in Lung Adenocarcinoma

open access: yesAdvanced Science, EarlyView.
This study reveals that metformin promotes glucuronic acid metabolism in lung adenocarcinoma by activating UGDH S476 phosphorylation and enhancing the conversion of UDPG to UDPGA based on metabolomics analysis. Through compound virtual screening, it is found that plantainoside targeting UGDH downstream UXS1 leads to UDPGA toxicity accumulation ...
Qihai Sui   +14 more
wiley   +1 more source

Use of progression criteria to support monitoring and commissioning decision making of public health services: lessons from Better Start Bradford

open access: yesBMC Public Health, 2019
Background Commissioning and monitoring of community-based interventions is a challenge due to the complex nature of the environment and the lack of any explicit cut-offs to guide decision making.
M. Bryant   +6 more
doaj   +1 more source

Social Enterprise in Denmark

open access: yes, 2018
This chapter provides a brief overview of the history of the Danish welfare state, an understanding of the institutional trajectory and legal forms of social enterprise. From a macro perspective, three major periods can be identified in the institutionalisation of Social Enterprise models in Denmark; such institutionalisation can also be approached by ...
Andersen, Linda Lundgaard   +2 more
openaire   +2 more sources

Natural Products Inspired Scaffold Diversification Leads to Unnatural Molecular Warhead and Covalent Strategy to Modulating Protein Function through Electrophilic Bromine Transfer

open access: yesAdvanced Science, EarlyView.
We report a new thiolate‐reactive α,α‐gem‐dibromo lactam warhead that activates transcription factor Nrf2 and demonstrates anti‐inflammatory activities, which have implications in cancer, neurodegeneration, and cardiovascular diseases. RNA‐seq illuminated detailed transcriptional profiles, and chemical reactions with cysteine‐containing compounds ...
Beau R. Brummel   +16 more
wiley   +1 more source

The identification of skills and competencies for effective management in social enterprises. A managerial perspective

open access: yesManagement, 2016
The need to adapt to external business requirements, turbulences present in the environment as well as the dynamic changes occurring in the non-profit sector require the presence of managers who are not only capable of taking proper care of financial ...
Wronka-Pośpiech Martyna
doaj   +1 more source

Social enterprise as a socially rational business [PDF]

open access: yes, 2006
What is the goal of social enterprise policy? Is it the creation of a ‘not-for-profit’ or ‘more-than-profit’ business movement? In institutional policy circles, arguments are shaped by the desire to protect assets for the community, while entrepreneurial
Ridley-Duff, R.
core  

Fibrates Inhibit PLTP‐induced M2 Macrophage Infiltration and Increase the Sensitivity of Hepatocellular Carcinoma to ICIs

open access: yesAdvanced Science, EarlyView.
Phospholipid transfer protein(PLTP) plays a critical role in forming a complex with kinase A (AURKA) and P65. This interaction facilitates phosphorylation of P65 at Ser536, leading to the activation of the NF‐κB signaling pathway. Ultimately, this leads to the upregulation of downstream cytokines, including IL‐6, IL‐8, and CSF‐1, which promotes M2 ...
Xinyue Liang   +14 more
wiley   +1 more source

Social enterprise in the UK homelessness sector: Lessons for Kazakhstan

open access: yesCogent Social Sciences, 2016
Kazakhstan’s homelessness social enterprise (SE) practitioners tend to argue that core to the SE concept is the idea that this is first and foremost a business whose income generation function enables it to sustain the viability of social projects.
Aslan S. Tanekenov
doaj   +1 more source

Finding Australia’s social enterprise sector: final report [PDF]

open access: yes, 2010
Executive Summary Social enterprises are organisations that: Are led by an economic, social, cultural, or environmental mission consistent with a public or community benefit; Trade to fulfil their mission; Derive a substantial portion of their ...
Heather Anderson   +3 more
core   +2 more sources

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