Results 131 to 140 of about 932,063 (293)
Advanced Science, EarlyView.This study designs a novel mRNA‐LNP vaccine targeting VZV glycoprotein E (gE) for herpes zoster via an AI‐assisted pipeline. Validated in mice and rhesus macaques, the mRNA‐LNP vaccine shows strong humoral and cellular immune responses, with CD4+ T‐cell responses more effective and durable than Shingrix, offering a promising prophylactic option ...
Kai Dong +6 more
wiley +1 more source
Corporate Social Responsibility: The Challenge for Medium Sized Enterprises in the Bamberg-Forcheim Region, Germany [PDF]
Globalization and the growing pressure on medium sized enterprises to take responsibility for their operations has resulted in an increasing number of medium sized companies becoming aware of Corporate Social Responsibility.
Malte Kaufmann, Viorica Şerban
core
Versatile CRISPR‐Cas Tools for Gene Regulation in Zebrafish via an Enhanced Q Binary System
Advanced Science, EarlyView.This study introduces CRISPR‐Q, a transgenic CRISPR‐Cas system leveraging the QFvpr/QUAS binary expression platform in zebrafish. CRISPR‐Q overcomes previous challenges in achieving stable and efficient gene regulation. By enabling precise spatiotemporal control of transcript knockdown (CRISPR‐QKD) and gene activation (CRISPR‐Qa), it provides a ...
Miaoyuan Shi +13 more
wiley +1 more source
Associations between culture of health and employee engagement in social enterprises: A cross-sectional study. [PDF]
PLoS One, 2021 Nekula P, Koob C.
europepmc +1 more source
Advanced Science, EarlyView.Phospholipid transfer protein(PLTP) plays a critical role in forming a complex with kinase A (AURKA) and P65. This interaction facilitates phosphorylation of P65 at Ser536, leading to the activation of the NF‐κB signaling pathway. Ultimately, this leads to the upregulation of downstream cytokines, including IL‐6, IL‐8, and CSF‐1, which promotes M2 ...
Xinyue Liang +14 more
wiley +1 more source
Wage differentials in social enterprises [PDF]
In Italy social enterprises include more than 7,000 institutions with around 250,000 workers serving more than three million people, a big share of which disadvantaged.
Becchetti, Leonardo, Castriota, Stefano
core
Social enterprise as a model for developing Aboriginal lands [PDF]
, 2013 Common property (communal land) is often viewed negatively with some claiming that communal land ownership and the absence of private property rights more generally have been insurmountable barriers to Indigenous enterprise.
Sean Kerins
core +1 more source
ITGB1 Regulates Triple‐Negative Breast Cancer Development by Modulating the Tumor Microenvironment
Advanced Science, EarlyView.ABSTRACT Tumorigenesis and metastasis are frequently attributed to the intricate interplay between cancer cells and the tumor microenvironment (TME). Comprehending the mechanisms and key regulators of cancer‐immune crosstalk in the TME is imperative for developing efficacious immunotherapy.
Nuozi Song +12 more
wiley +1 more source
Impact of the Optimistic Perspective on the Intention to Create Social Enterprises: A Comparative Study Between Portugal and Spain. [PDF]
Front Psychol, 2021 Margaça C +3 more
europepmc +1 more source
Advanced Science, EarlyView.The functional schematic diagram of tumor associated neutrophils. Abstract Enhancing cervical cancer (CC) immunotherapy requires deciphering the heterogeneous tumor immune microenvironment (TIME), particularly neutrophil phenotypic dynamics. Here, 1) we collected 543 CC cases to find that patients with elevated neutrophil levels have a higher incidence
Xingyu Chang +7 more
wiley +1 more source