Results 61 to 70 of about 167,140 (263)

Who are we leaving behind? Mobilising exercise professionals to improve mental health and social equity

Translational Exercise Biomedicine
Clinical exercise professionals (CEPs) play a key role in supporting people with mental and physical health challenges. Yet access to services is inequitable, especially for ‘hard to reach’ or underserved populations such as people who have experienced ...
Mastrogiovanni Chiara, Lederman Oscar, Wright Kemi, McKeon Grace, Teasdale Scott, Anwar Afsana, Bachtiar Farahdina, Choudhry Uzma, Rosenbaum Simon   +8 more
doaj   +1 more source

Concerted Action of Targeted Nucleic Acid Therapeutics as Flexible, Precision and Personalized Cancer Treatment

Advanced Science, EarlyView.
Combinations of small activating RNAs and small interfering RNAs were developed as personalized precision therapies that simultaneously activate tumor suppressors and silence oncogenes according to the molecular signatures of patient tumors. This combination strategy demonstrated superior anticancer efficacy, highlighting the promise of precision ...
Jing Wu, Jiaxuan Chen, Abdechakour Elkihel, Wenjun Lan, Nicolas Fraunhoffer, Dandan Zhu, Baoping Lian, Christina Galanakou, Zhancun Bian, Xi Liu, Odile Gayet, Loic Moubri, Julie Aglietti Roques, Vikash Reebye, Nagy Habib, Xiaoxuan Liu, Nelson Dusetti, Juan Lucio Iovanna, Ling Peng   +18 more
wiley   +1 more source

A Novel Pak1 Activator Ameliorates ER Stress for HFpEF Therapy

Advanced Science, EarlyView.
Chronic metabolic stress is a major contributor to HFpEF progression. Under prolonged metabolic stress, Pak1 activity becomes impaired, contributing to disrupted ER proteostasis, cardiomyocyte apoptosis, fibrosis, and diastolic dysfunction. Mechanistically, Pak1 overexpression activates the ERK1/2–MNK1–eIF4E signaling axis, promotes translational ...
Honglin Xu, Hongyuan Zhang, Tayyiba Azam, Susanne S. Hille, Yingjuan Liu, Min Zi, Jiaqing Lang, He Yu, Yujia Cao, Bernard D. Keavney, Tamer M. A. Mohamed, Jessica M. Miller, Riham R. E. Abouleisa, Ming Xu, Elizabeth J. Cartwright, Oliver J. Müller, Ming Lei, Xin Wang   +17 more
wiley   +1 more source

Closing the pain divide: the quest for effective universal health coverage

The Lancet Global Health, 2015
Background: More than 5·5 billion people, most in low-income and middle-income income countries (LMICs), live with limited or no access to pain control and palliative care. This inequality—the pain divide—is a grave injustice.
Dr. F M Knaul, PhD, A Bhadelia, MS, H Arreola Ornelas, MSc, L de Lima, MS, M del Rocio Sáenz Madrigal, MD   +4 more
doaj   +1 more source

Molecular Design Strategies for High‐Voltage Organic Cathodes

Advanced Energy Materials, EarlyView.
This work proposes molecular engineering strategies for high‐voltage organic cathode materials for Li‐ion batteries: (1) increase Li‐O coordination number (CN), (2) achieve a greater increase in aromaticity upon reduction (∆Aromaticity), and (3) add an electron‐withdrawing group (EWG), through a combined experimental and computational study on reported
Sungil Hong, Alae Eddine Lakraychi, Artur Lyssenko, Abhishek Ashwin Panchal, Harshan Reddy Gopidi, Pieremanuele Canepa, Rafael Gómez‐Bombarelli, Yan Yao, Rajeev Surendran Assary   +8 more
wiley   +1 more source

Understanding needs and solutions to promote healthy ageing and reduce multimorbidity in Rwanda: a protocol paper for a mixed methods, stepwise research study

BMJ Open
Introduction Ageing is often accompanied by chronic diseases, multimorbidity and frailty, increasing the need for clinical and social care to support healthy ageing and manage these conditions.
Carolyn A Greig, Lisa R Hirschhorn, Justine Davies, Alemayehu Amberbir, Chester Kalinda, Francois Uwinkindi, Tsion Yohannes, Michael Boah, Callixte Cyuzuzo, Sandra Isano, Robert Ojiambo   +10 more
doaj   +1 more source

Race and Social Equity [PDF]

, 2015
In this compelling book the author contends that social equity--specifically racial equity--is a nervous area of government. Over the course of history, this nervousness has stifled many individuals and organizations, thus leading to an inability to seriously advance the reduction of racial inequities in government.
openaire   +1 more source

Extreme Weather Events and Consumer Food Responses

Applied Economic Perspectives and Policy, EarlyView.
ABSTRACT This study investigates consumer food responses to Hurricanes Helene and Milton, which affected a swath of the Southeastern U.S. in 2024. Using representative consumer survey data from six affected states, we analyze 10 distinct food responses classified into ex ante and ex post responses, and examine their associations with food insufficiency
Ahmad Zia Wahdat, Joseph Balagtas
wiley   +1 more source

Low-cost simulation models for soft-tissue procedures for medical student education in Rwanda

BMC Medical Education
Background Simulation-based training (SBT) enhances medical education but is often limited in low-resource settings. This study aimed to describe the development, use, and cost implication of three low-cost models of soft tissue lesions for SBT of ...
Rachel E. Wittenberg, Mayte Bryce-Alberti, Natnael Z. Shimelash, Ornella Masimbi, Lauren E. Kratky, Avery A. Thompson, Omar Alali, Madeleine Carroll, Sarah R. Nuss, Matthew T. Hey, Lilli Gordon, Radzi Hamzah, Kiana Winslow, Isaac G. Alty, Rashi Jhunjhunwala, Callum Forbes, Andrew Eyre, Robert Riviello, Abebe Bekele, Geoffrey A. Anderson, Barnabas Tobi Alayande   +20 more
doaj   +1 more source

Dynamics of Unemployment Duration Among African Migrants in Sweden: 'The contribution of specific country of birth and gender on employment success'

Nordic Journal of Migration Research, 2015
This study uses Cox proportional hazard models to examine the likelihood of transition to first employment among specific groups of African migrants compared to the general population and other immigrants, respectively, in Sweden.
Hélio Manhica, John Östh, Mikael Rostila   +2 more
doaj   +1 more source