Results 41 to 50 of about 44,184 (210)

Patients, payers and developers of Orphan Medicinal Products: lessons learned from 10 years’ multi-stakeholder dialogue on improving access in Europe via MoCA

Orphanet Journal of Rare Diseases, 2023
Background The Mechanism of Coordinated Access to Orphan Medicinal Products (MoCA) was established in 2013 with the intention of developing a coordinated mechanism between volunteering EU stakeholders and developers of Orphan Medicinal Products (OMPs) to
Maria Cavaller-Bellaubi, Wills Hughes-Wilson, Šárka Kubinová, Marc Van de Casteele, Evert Jan Van Lente, Emanuele Degortes, Johan Pontén, Hans-Georg Eichler, Yann Le Cam, Simone Boselli, Anna Bucsics   +10 more
doaj   +1 more source

Collaborating as peers or targeted by science diplomacy? The participation of Latin American researchers in the European Framework Programme for Research and Innovation

Tapuya, 2022
In this paper, we discuss whether Latin American researchers participate in the European Research and Innovation Framework Programme (FP) by joining European colleagues as peers, or by being targeted as part of a science diplomacy initiative.
Consuelo Uribe-Mallarino
doaj   +1 more source

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

Outpatient services and primary care: scoping review, substudies and international comparisons

Health Services and Delivery Research, 2016
Aim: This study updates a previous scoping review published by the National Institute for Health Research (NIHR) in 2006 (Roland M, McDonald R, Sibbald B.
Eleanor Winpenny, Céline Miani, Emma Pitchforth, Sarah Ball, Ellen Nolte, Sarah King, Joanne Greenhalgh, Martin Roland   +7 more
doaj   +1 more source

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

‘For a Social Europe’

, 2022
Abstract This chapter examines the efforts undertaken by the then rising European Left—especially European socialist parties—to finally outline a concrete programme for a ‘social Europe’ in the run-up to the adoption of the European Community’s (EC’s) first Social Action Programme (1972–4).
openaire   +1 more source

An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes

FEBS Letters, EarlyView.
GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg, Martine Hjeltnes, Josephine Krieger, Joshua E. Elias, Maria Stensland, Kristian Holm, Xiaojun Jiang, Chuki Khangsar, Tuula A. Nyman, Arthur Kaser, Johannes R. Hov, Tom H. Karlsen, Nicole C. Kaneider, Frode L. Jahnsen, Georg Schneditz   +14 more
wiley   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

CHINESE-RUSSIAN PARTNERSHIP AND STRATEGIC COOPERATION

Сравнительная политика, 2019
For most of the time since the establishment of the Chinese-Russian strategic partnership, diplomatic interaction was the main area of strategic cooperation between the two parties.
Liu Fenghua
doaj   +1 more source

Opinion of society as a basis of international relations — analysis of data of public-opinion polls «how citizens of China cognize the world?» [PDF]

Экономика региона, 2012
International links of China were intensified with the realization of policy of reforms. It becomes relevant to understand, how citizens of China cognize the world.
Pan Daly
doaj   +1 more source