Results 41 to 50 of about 333,781 (261)

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source

On the road to intersectional mainstreaming? EU (gender) equality policy between intersectionality and anti-gender backlash

Global Social Challenges Journal
In the wake of the 2024 European Parliament elections and the subsequent recast of the European Commission, this article looks at the opportunities that have not yet been fully exploited to further advance gender equality in the European Union. Crucially,
Katrin Lange, Julia Lux
doaj   +1 more source

CONSEQUENCES OF GLOBALIZATION: MENTAL STRESS IN MANAGEMENT [PDF]

Zeszyty Naukowe Wyższej Szkoły Finansów i Prawa w Bielsku-Białej, 2017
Due to mass consolidation and permanent restructuring of process flows in a global context, people are increasingly falling into routine and predetermined life patterns.
Frantisek DROZEN, Rudolf BRABECK
doaj   +1 more source

The Determinants of Social Connectedness in Europe [PDF]

, 2020
Abstract We use de-identified and aggregated data from Facebook to study the structure of social networks across European regions. Social connectedness declines strongly in geographic distance and at country borders. Historical borders and unions—such as the Austro-Hungarian Empire, Czechoslovakia, and East/West Germany—shape present-day social ...
Michael C. Bailey, Drew Johnston, Theresa Kuchler, Dominic Russel, Bogdan State, Johannes Stroebel   +5 more
openaire   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Eco-social market economy as an European innovation

Agricultural Economics (AGRICECON), 2003
The paper presents fundamental ideas of European social market economy that are to be applied to formulate the "European Model of Agriculture". In connection with the needs of further development of the Common Agricultural Policy, food strategy and ...
J. Riegler
doaj   +1 more source

Patients, payers and developers of Orphan Medicinal Products: lessons learned from 10 years’ multi-stakeholder dialogue on improving access in Europe via MoCA

Orphanet Journal of Rare Diseases, 2023
Background The Mechanism of Coordinated Access to Orphan Medicinal Products (MoCA) was established in 2013 with the intention of developing a coordinated mechanism between volunteering EU stakeholders and developers of Orphan Medicinal Products (OMPs) to
Maria Cavaller-Bellaubi, Wills Hughes-Wilson, Šárka Kubinová, Marc Van de Casteele, Evert Jan Van Lente, Emanuele Degortes, Johan Pontén, Hans-Georg Eichler, Yann Le Cam, Simone Boselli, Anna Bucsics   +10 more
doaj   +1 more source

Collaborating as peers or targeted by science diplomacy? The participation of Latin American researchers in the European Framework Programme for Research and Innovation

Tapuya, 2022
In this paper, we discuss whether Latin American researchers participate in the European Research and Innovation Framework Programme (FP) by joining European colleagues as peers, or by being targeted as part of a science diplomacy initiative.
Consuelo Uribe-Mallarino
doaj   +1 more source

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source