Results 51 to 60 of about 14,849,092 (336)

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

open access: yesFEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Organizing the interface—Plasma membrane architecture and receptor dynamics in virus‐cell interactions

open access: yesFEBS Letters, EarlyView.
Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley   +1 more source

Social Europe: A Manifesto

open access: yes, 2020
The European Union is excellently equipped to pursue the most urgent issues facing the advanced world: combating environmental damage and climate change, coping with the massive aftermath of the coronavirus crisis, reforming globalisation, regulating ...
Crouch, C.
core  

CONSEQUENCES OF GLOBALIZATION: MENTAL STRESS IN MANAGEMENT [PDF]

open access: yesZeszyty Naukowe Wyższej Szkoły Finansów i Prawa w Bielsku-Białej, 2017
Due to mass consolidation and permanent restructuring of process flows in a global context, people are increasingly falling into routine and predetermined life patterns.
Frantisek DROZEN, Rudolf BRABECK
doaj   +1 more source

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

open access: yesFEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

On the road to intersectional mainstreaming? EU (gender) equality policy between intersectionality and anti-gender backlash

open access: yesGlobal Social Challenges Journal
In the wake of the 2024 European Parliament elections and the subsequent recast of the European Commission, this article looks at the opportunities that have not yet been fully exploited to further advance gender equality in the European Union. Crucially,
Katrin Lange, Julia Lux
doaj   +1 more source

What Is 'Victory' in the Orthodox Christian Ethics of War?

open access: yesLabyrinth: An International Journal for Philosophy, Value Theory and Sociocultural Hermeneutics, 2021
The text reconstructs the protocol of 'victory' as part of the interruption of enmity and establishment of temporary peace. Different understandings of the enemy and enmity imply that victory in war and cessation of conflict can essentially determine ...
Petar Bojanić
doaj   +1 more source

Investigating transcription factor dynamics in health and disease using FRAP

open access: yesFEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj   +3 more
wiley   +1 more source

The Determinants of Social Connectedness in Europe [PDF]

open access: yes, 2020
Abstract We use de-identified and aggregated data from Facebook to study the structure of social networks across European regions. Social connectedness declines strongly in geographic distance and at country borders. Historical borders and unions—such as the Austro-Hungarian Empire, Czechoslovakia, and East/West Germany—shape present-day social ...
Michael C. Bailey   +5 more
openaire   +1 more source

I’m Still Standing: Transposition and political impact of the Directive on Adequate Minimum Wages in the EU

open access: yesItalian Labour Law e-Journal
More than one year after the deadline for the transposition of the European Minimum Wage Directive into national law, this contribution analyses the impact which the Directive already had on minimum wage setting and collective bargaining at national ...
Torsten Müller
doaj   +1 more source

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