Results 101 to 110 of about 13,492,077 (298)
Molecular Oncology, EarlyView.Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura +19 more
wiley +1 more source
Molecular Oncology, EarlyView.We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober +16 more
wiley +1 more source
Policies and Practices for Mental Health in Europe Meeting the Challenges
, 2008 Countries in the WHO European Region are committed to transforming their mental health programmes and activities, shifting from institutional practices to person-centred community-based care.
Europe, WHO Regional Office for
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Social Classes and Social Mobility in Slovenia and Europe
Organizacija, 2008 Social Classes and Social Mobility in Slovenia and Europe In closed social systems the social position of an individual is determined by the social position of the family into which he or she was born, whereas in open social systems mobility from one social class to another is possible. This paper concerns the relationship between the
Jereb, Eva, Ferjan, Marko
openaire +2 more sources
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer
Molecular Oncology, EarlyView.Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola +11 more
wiley +1 more source
SPARC Europe Annual Report 2024 [PDF]
En réfléchissant aux faits saillants de SPARC Europe en 2024 et la conclusion de sa Stratégie 2021-2024, ce qui ressort le plus : c\u27est l’engagement croissant des communautés avec lesquelles ils travaillent.
SPARC Europe
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Molecular Oncology, EarlyView.Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur +11 more
wiley +1 more source
Europeanization, Enlargement and Social Policy in Central and Eastern Europe [PDF]
This paper aims at exploring the relationship between Europeanization, Enlargement andsocial policy developments in Central and Eastern Europe. In particular, it examines theimportance of ideas, interests and institutions in the making of contemporary ...
Alfio Cerami
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Health and Social Care Delivery ResearchBackground General practices are facing challenges such as rising patient demand and difficulties recruiting and retaining general practitioners. Greater use of digital technology has been advocated as a way of mitigating some of these challenges and ...
Jennifer Newbould +3 more
doaj +1 more source