Results 61 to 70 of about 2,484,514 (308)
Molecular Oncology, EarlyView.Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova +25 more
wiley +1 more source
COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells
Molecular Oncology, EarlyView.This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos +6 more
wiley +1 more source
Psikiyatride Güncel YaklaşımlarThis review study comparatively examines three fundamental theoretical approaches attachment theory, social exchange theory, and the investment model in explaining the phenomenon of loyalty in close relationships.
Bahadır Şahin Kamas, Tolga Seki
doaj +1 more source
Defining sex and virginity loss [PDF]
, 2011 This study has examined definitions of sex and virginity loss and the influence of gender, religiosity, middle school sex education, and the importance of virginity on those definitions. The study also tests the applicability of social exchange theory to
Wright, Matthew R.
core +1 more source
, 2017 Purpose This paper aims to investigate customers’ perceptions of the service quality facets of Airbnb accommodation using social exchange theory as a suitable conceptual framework to explain aspects of interactivity between guests and hosts.
Constantinos-Vasilios Priporas +3 more
semanticscholar +1 more source
Digital twins to accelerate target identification and drug development for immune‐mediated disorders
FEBS Open Bio, EarlyView.Digital twins integrate patient‐derived molecular and clinical data into personalised computational models that simulate disease mechanisms. They enable rapid identification and validation of therapeutic targets, prediction of drug responses, and prioritisation of candidate interventions.
Anna Niarakis, Philippe Moingeon
wiley +1 more source
Teacher and student psychological contract: a review of research
Вестник Мининского университетаIntroduction. The article presents a theoretical analysis of the relationships that develop between participants in the educational process. The main idea is that teaching and upbringing are neither a one-sided, purposeful influence of a teacher on a ...
M. A. Gagarina
doaj +1 more source
Opinion Exchange Dynamics [PDF]
, 2017 We survey a range of models of opinion exchange. From the introduction: "The exchange of opinions between individuals is a fundamental social interaction...
Mossel, Elchanan, Tamuz, Omer
core +4 more sources
FEBS Open Bio, EarlyView.Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane +11 more
wiley +1 more source
Optimizing photoactivation of PA‐mCherry for optical pooled CRISPR screens
FEBS Open Bio, EarlyView.Photoactivatable PA‐mCherry finds widespread use to optically tag individual cells. However, confocal 405 nm UV laser‐scanning (normal scan) is much less efficient than widefield UV illumination, limiting the use of PA‐mCherry on confocal instruments. We remedy this limitation by reporting that rapid and repeated confocal scanning with a low‐intensity,
Sravasti Mukherjee +3 more
wiley +1 more source