Results 131 to 140 of about 1,835,724 (288)
Outsider and Insider Expertise: The response of residents of deprived neighbourhoods to an academic definition of social exclusion [PDF]
The aim of this paper is to compare academic interpretations of the term social exclusion with the understanding of people with direct experience of the phenomenon.
Julian Le Grand, Liz Richardson
core
Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma
Molecular Oncology, EarlyView.The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic +5 more
wiley +1 more source
Defense or attack? Can soccer clubs help tackle social exclusion? [PDF]
, 2004 This paper examines soccer as a social and cultural phenomenon which is increasingly being adopted as an instrument for social change. The economic power of soccer in the UK, and in many other parts of the world, is apparent with the fame and wealth ...
Holden, Philip, Wilde, Nicholas
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Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
Molecular Oncology, EarlyView.Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova +14 more
wiley +1 more source
Revista Interdisciplinar de Direito, 2009 Despite technological advances are increasingly signifi cant and were followed by mil-lions of people, there is still a large number of individuals who lack access to basic technolo-gies, and so little to their innovations.
Marco Antônio Pereira Araújo
doaj
CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3
Molecular Oncology, EarlyView.PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh +12 more
wiley +1 more source
Delito, violencia y exclusión social
Question, 2011 En Sociología del delito amateur, Gabriel Kessler se propone un abordaje del delito y la violencia como parte de una reflexión más amplia sobre la cuestión social.
Claudiana Shirli Pereson
doaj
Social Exclusion and the Future of Cities [PDF]
In both Britain and the United States, people have been moving away from the inner cities to suburban developments, often leaving behind concentrations of poverty and decaying neighbourhoods. Anne Power's paper focuses on the British situation.
Anne Power, William Julius Wilson
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KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer
Molecular Oncology, EarlyView.Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan +16 more
wiley +1 more source