Results 101 to 110 of about 1,304,060 (311)

A light‐triggered Time‐Resolved X‐ray Solution Scattering (TR‐XSS) workflow with application to protein conformational dynamics

FEBS Open Bio, EarlyView.
Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei, Fredrik Orädd, Konstantinos Magkakis, Magnus Andersson   +3 more
wiley   +1 more source

Regulatory effect of Ganoderma lucidum and its active components on gut flora in diseases

Frontiers in Microbiology
Driven by the good developmental potential and favorable environment at this stage, Ganoderma lucidum is recognized as a precious large fungus with medicinal and nutritional health care values. Among them, polysaccharides, triterpenoids, oligosaccharides,
Xinjie Qin, Xinjie Qin, Zinan Fang, Zinan Fang, Jinkang Zhang, Jinkang Zhang, Wenbo Zhao, Wenbo Zhao, Ni Zheng, Ni Zheng, Xiaoe Wang, Xiaoe Wang   +11 more
doaj   +1 more source

Single‐molecule DNA flow‐stretch assays for high‐throughput DNA–protein interaction studies

FEBS Open Bio, EarlyView.
We describe an optimised single‐molecule DNA flow‐stretch assay that visualises DNA–protein interactions in real time. Linear DNA fragments are tethered to a surface and stretched by buffer flow for fluorescence imaging. Using λ and φX174 DNA, this protocol enhances reproducibility and accessibility, providing a versatile approach for studying diverse ...
Ayush Kumar Ganguli, Mohammad Nour Alsamsam, Ugnė Bagdonaitė, Van Truc Vu, Chun‐Jen Huang, Polina Kuzhir, Mindaugas Zaremba, Aurimas Kopūstas, Marijonas Tutkus   +8 more
wiley   +1 more source

Integration of sentinel surveillance and climate factors to accelerate malaria elimination in a changing climate of Senegal

Science in One Health
Background: Senegal is located in a malaria-endemic zone. Malaria is a highly climate-sensitive vector-borne disease, yet its sentinel surveillance shows a weak integration of malaria morbidity data with climatic factors.
Ibrahima Mamby Keita, Mariama Diouf, Medoune Ndiop, Boly Diop, Khaly Gueye, Marianne Kouawo, Ousmane Ndiaye, Doudou Sene, Elhadji Mamadou Ndiaye, Marie Khemesse Ngom Ndiaye   +9 more
doaj   +1 more source

Editor’s notes : Socio-pedagogical knowledge expertise across the social care sectors in Northern Europe

, 2018
A major challenge in contemporary welfare societies is the delivery of services affirming people’s expectations for their life standard, health and social care services.
Dychawy Rosner, Irena,, Irena Dychawy Rosner, Dychawy Rosner, Irena, Irena, Dychawy Rosner,   +3 more
core   +1 more source

Matrix metalloproteinase‐9 regulates cell adhesion and membrane protrusive activity of ovarian cancer cells

FEBS Open Bio, EarlyView.
Matrix metalloproteinase‐9 (MMP9) drives ovarian cancer progression. Using MMP9‐null cells (M9‐KO) created from ovarian cancer cells, we found MMP9 loss did not block Epidermal Growth Factor (EGF)‐driven E‐cadherin dissolution or EMT but delayed and reduced EGF‐driven membrane protrusions. Transient MMP9 re‐expression drove membrane protrusion.
Claire Strauel, Sam Bennett, Natalie Ehlinger, Nelson Cook, Katelyn Marvin, Caleb L. Lines, Sam Reyes, Brooke Kirby, Shawn M. Ellerbroek   +8 more
wiley   +1 more source

Suppression of lung adenocarcinoma migration through organelle alkalization by human lactoferrin – albumin fusion

FEBS Open Bio, EarlyView.
This paper reveals how human lactoferrin–albumin fusion (hLF‐HSA) potently suppresses lung adenocarcinoma cell migration. hLF‐HSA upregulates NHE7, leading to Golgi alkalization, disruption of the Golgi secretome, downregulation of MMP1, and reversal of EMT. These findings suggest a novel Golgi‐targeting strategy to suppress cancer cell migration.
Hana Nopia, Masahiro Kimura, Daisuke Kurimoto, Atsushi Sato   +3 more
wiley   +1 more source

From the nest to the world: helicopter parenting and challenges in young adult social integration

Frontiers in Psychology
IntroductionHelicopter parenting is a new parenting style that has become widespread globally. This study aimed to evaluate the effects of helicopter parenting experiences on Turkish young adults, focusing on self-determination and fear of intimacy ...
Yelda Yilmaz, Taner Artan, Taner Artan, Farida Gurbanova, Nargiz Aliyeva   +4 more
doaj   +1 more source

Why human connection is the true metric of research success

FEBS Open Bio, EarlyView.
Human‐centred mentorship can be shaped by mentor attributes, actions, intrinsic drive and career ambition. Drawing on reflections across Singapore and France, as well as workshop insights from FEBS‐IUBMB ENABLE 2024, this article shows that human‐centred mentorship creates the conditions for sustainable growth, well‐being and retention in research ...
Timothy Lin Yun Tan, Mattias Wei Ren Kon, Xavier Coumoul, Fun Man Fung   +3 more
wiley   +1 more source

Long‐term hippocampal alterations and cognitive impairment in a murine model of surgical sepsis

FEBS Open Bio, EarlyView.
Using a mouse model of surgical sepsis, we tested long‐term memory and analyzed the transcriptome of single cells isolated from the hippocampus. Survivor mice showed worse memory, loss of certain brain cell subpopulations, and abnormal immune cell activity—suggesting that post‐sepsis brain alterations may be linked to cognitive deficits.
Dong Seong Cho, Rebecca Schmitt, Aneesha Dasgupta, Alexandra Ducharme, Jason Doles   +4 more
wiley   +1 more source