Results 61 to 70 of about 1,304,060 (311)
Modulation of Homer1 EVH1 domain internal dynamics by putative autism‐associated mutations
FEBS Letters, EarlyView.The putative autism‐associated M65I and S97L variants of the EVH1 domain of the postsynaptic scaffold protein Homer1 do not exhibit substantial changes in their overall structure or partner binding. Both of them, but especially the M65I variant, show altered internal dynamics relative to the wild‐type domain on the μs‐ms timescale, indicated by the ...
Fanni Farkas +6 more
wiley +1 more source
The ubiquitin‐proteasome system and autophagy as guardians of the cellular proteome
FEBS Letters, EarlyView.This Perspective covers the three principles governing the crosstalk between the ubiquitin‐proteasome system and autophagy in cellular proteostasis: (1) a shared ubiquitin code routing substrates via shuttle factors or autophagy receptors; (2) spatial compartmentalization into phase‐separated degradation hubs and organelle‐specific modules (exemplified
Ivan Dikic
wiley +1 more source
An Outline of the Changes in Slovak Literary Criticism from the Mid-1960s to the Early 1970s. (3th Part) [PDF]
Slovenska Literatura, 2015 This literary history paper is concerned with the changes of Slovak literary criticism over a certain period of time. It reconstructs the process of the criticism becoming temporarily emancipated, i.e.
Vladimír Barborík
doaj
The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers
Molecular Oncology, EarlyView.The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce +11 more
wiley +1 more source
, 2019 [Extract] Field education is marginalized in social work education, an area of academic practice which social work educators can be reluctant to continue.
Zuchowski, Ines
core
Aportaciones innovadoras a los procesos metodológicos en pedagogía social [PDF]
, 2011 En este proyecto presentado en el curso 2009-10, hemos conseguido ampliar los conocimientos del alumnado en el uso de las nuevas tecnologías aplicadas al campo de la Pedagogía Social.
Gallardo-López, José Alberto +2 more
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Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source
Community engagement: managers’ viewpoints
, 2011 Managers are invaluable for their support of fieldwork placement for social work students. This chapter examines factors that influence managers’ decision-making towards student placement provision, a role which has traditionally been overlooked in the ...
Hanlen, Patricia
core
Molecular Oncology, EarlyView.Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch +13 more
wiley +1 more source
Social work field education in Australia: sharing practice wisdom and reflection
, 2014 This paper highlights current issues relevant for Australian social work field education preparation and delivery, and shares some of the challenges that impact on schools of social work in rural, regional and urban settings. Topics discussed include the
Diamandi, Sophie +4 more
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