Results 121 to 130 of about 165,151 (308)

ATP13A2 is involved in intracellular polyamine transport in lung epithelial cells

open access: yesFEBS Open Bio, EarlyView.
Spermidine transport in lung epithelial cells involves the polyamine transporter ATP13A2. Cell proliferation is associated with the upregulation of ATP13A2. Polyamines are present in all living cells and are implicated in various crucial cellular processes such as proliferation, apoptosis and autophagy.
Yuta Hatori   +8 more
wiley   +1 more source

Social Mobility and Equality of Opportunity Geary Lecture Spring 2010 [PDF]

open access: yes
Ladies and gentlemen, director, colleagues and friends: it is a great honour and a pleasure to be asked to deliver this year’s Geary lecture, coming, as it does, on the 50th anniversary of the founding of the Economic and Social Research Institute (ESRI).
Richard Breen
core  

TMC4 localizes to multiple taste cell types in the mouse taste papillae

open access: yesFEBS Open Bio, EarlyView.
Transmembrane channel‐like 4 (TMC4), a voltage‐dependent chloride channel, plays a critical role in amiloride‐insensitive salty taste transduction. TMC4 is broadly expressed in all mature taste cell types, suggesting a possible involvement of multiple cell types in this pathway.
Momo Murata   +6 more
wiley   +1 more source

Class and Ethno-Gender Differences in Education and Labour Market Position—An Intersectional Analysis of Ethnic Integration in the UK

open access: yesSocieties
This paper analyses the socio-economic disadvantages of women from different ethnic minority heritages in the UK. Using data from the Labour Force Survey (2014–2023), which contains detailed information on parental class and respondents’ socio-economic ...
Yaojun Li
doaj   +1 more source

Party system institutionalisation in east-central Europe: empirical dimensions and tentative conclusions [PDF]

open access: yes, 2008
The nationalisation of party systems is a topic closely related to processes of party system institutionalisation, an area that has developed its own literature and dimensions of analysis.
Lewis, Paul G.
core  

Metformin promotes mitochondrial integrity through AMPK‐signaling in Leber's hereditary optic neuropathy

open access: yesFEBS Open Bio, EarlyView.
Metformin mediates mitochondrial quality control in Leber's hereditary optic neuropathy (LHON) fibroblasts carrying mtDNA mutations. At therapeutic levels, metformin activates AMPK signaling to restore mitochondrial dynamics by promoting fusion and restraining fission, while preserving mitochondrial mass, enhancing autophagy/mitophagy and biogenesis ...
Chatnapa Panusatid   +3 more
wiley   +1 more source

The systemic mind and a conceptual framework for the psychosocial environment of business enterprises: Practical implications for systemic leadership training [PDF]

open access: yes, 2015
This chapter introduces a research-based conceptual framework for the study of the inner psychosocial reality of business enterprises. It is called the Inner Organizational Ecosystem Approach (IOEA).
Parma, Petr, Trnka, Radek
core  

Engineering tandem VHHs to target different epitopes to enhance antibody‐dependent cell‐mediated cytotoxicity

open access: yesFEBS Open Bio, EarlyView.
Tandem VHH targeting distinct EGFR epitopes were engineered into a monovalent bispecific antibody (7D12‐EGA1‐Fc) with more potent ADCC without increasing affinity to EGFR. Structural modeling of 7D12‐EGA1‐Fc showed cross‐linking of separate EGFR domains to enhance CD16a engagement on NK cells.
Yuqiang Xu   +5 more
wiley   +1 more source

Selected aspects of social space as the basis for understanding the »modernisation« of higher education [PDF]

open access: yesDružboslovne Razprave, 2018
Based on selected aspects of the social space, we establish a conceptual model for developing indicators of the »modernisation« of higher education systems.
Samo Pavlin
doaj  

Exploring continuous organisational transformation as a form of network interdependence [PDF]

open access: yes, 2008
In this paper we examine the problematic area of continuous transformation. We conduct our analysis from three theoretical perspectives: the resource based view, social network theory, and stakeholder theory. We found that the continuous transformation
Braganza, A, Stebbings, H
core  

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