Results 121 to 130 of about 2,065,924 (290)
Mass spectrometry based identification of AMP‐O‐Tris generated by Thermococcus onnurineus Cas10
FEBS Open Bio, EarlyView.Isolated Thermococcus onnurineus Cas10 generates the noncanonical ATP‐derived product AMP‐O‐Tris while in Tris‐containing buffer as identified via mass spectrometry, revealing relaxed nucleophile selectivity under isolated conditions. These findings suggest that multiprotein Csm complex assembly restricts Cas10 reactivity toward canonical cyclic ...
Su‐Jin Lee +6 more
wiley +1 more source
An Analysis of a Modified Social Force Model in Crowd Emergency Evacuation Simulation
Applications of Modelling and Simulation, 2019 In crowd evacuation simulation, a number of exit point and obstacles play an important role that can influence the result in the evacuation simulation.
Hamizan Sharbini +2 more
doaj
Worker Absenteeism in Search Equilibrium [PDF]
The paper presents a tractable general equilibrium model of search unemployment that incorporates absence from work as a distinct labor force state.
Bertil Holmlund, Per Engström
core
Why human connection is the true metric of research success
FEBS Open Bio, EarlyView.Human‐centred mentorship can be shaped by mentor attributes, actions, intrinsic drive and career ambition. Drawing on reflections across Singapore and France, as well as workshop insights from FEBS‐IUBMB ENABLE 2024, this article shows that human‐centred mentorship creates the conditions for sustainable growth, well‐being and retention in research ...
Timothy Lin Yun Tan +3 more
wiley +1 more source
A Social Force-Based Model for Pedestrian Evacuation with Static Guidance in Emergency Situations
FireWith public safety receiving widespread attention from society, the question of how to effectively evacuate crowds has become a key issue. Leaders can provide pedestrians with clear and accurate route information and play an important role in daily crowd
Ping Zhang +5 more
doaj +1 more source
New Evidence on Financial Incentives and the Timing of Retirement [PDF]
We investigate the responsiveness of individual retirement decisions to changes in financial incentives. The causal effect is identified based on the natural experiment generated by an institutional reform.
Barbara Hanel, Regina T. Riphahn
core
FEBS Open Bio, EarlyView.Evolutionary analysis across 32 placental mammals identified positive selection at residues H148 and W149 in the immune receptor FcγR1. Ancestral reconstruction combined with molecular dynamics simulations reveals how these mutations may influence receptor structure and dynamics, providing insight into the evolution of antibody recognition and immune ...
David A. Young +7 more
wiley +1 more source
The trend in female labour force participation; what can be expected for the future? [PDF]
During the 1980s and 1990s, the Netherlands experienced a strong increase in the labour force participation of women. This study investigates the increase of participation over the successive generations of women, and produces an educated guess for ...
Daniel van Vuuren +2 more
core
FEBS Open Bio, EarlyView.Pharmacological inhibition of PERK in a DEN‐induced mouse model of liver cancer does not reduce tumor burden but alters cellular stress signaling. Despite blocking PERK activity, downstream stress responses, including CHOP expression, remain active, suggesting compensatory mechanisms within the unfolded protein response that may influence tumor ...
Ada Lerma‐Clavero +5 more
wiley +1 more source
FireAfter a fire breaks out, pedestrians simultaneously move towards the exit and quickly form a crowded area near the exit. With the intensification of pedestrians’ tendencies towards unfair competition, there is an increase in pushing and collisions within
Shanwei Liu +3 more
doaj +1 more source