Results 221 to 230 of about 14,389,788 (304)

Memoria de actividades del Consejo Económico y Social de Aragón.: 2011 [PDF]

, 2011
Consejo Económico y Social de Aragón., Consejo Económico y Social de Aragón   +1 more
core  

Regulation of the lncRNA NEAT1 by p53‐ΔNp63 crosstalk modulates the DNA damage response and therapeutic efficacy in HNSCC

Molecular Oncology, EarlyView.
In head and neck squamous cell carcinoma (HNSCC) p53 and p63 exert opposite roles on the transcription regulation of the lncRNA NEAT1. Under basal conditions, p53 levels are low and p63 represses NEAT1 expression. Upon genotoxic stress, p53 is rapidly induced, displacing p63 from the NEAT1 promoter leading to NEAT1 transcriptional activation and ...
Sara De Domenico, Veronica La Banca, Silvia D'Amico, Stefano Scalera, Sara Nicolai, Angelo Peschiaroli   +5 more
wiley   +1 more source

Beyond the autonomous individual: hydrosocial relations and the constitution of the relational hydrosocial self in an Andean conflict. [PDF]

Front Sociol
Oré Gálvez SF, Molina Linares AF, Phocco Minaya JL, Quispe Quispe A, Carhuallanqui Ibarra SD, Terres León JC, Ñaupari Molina R, Barnes CHW, Valladares LLS.   +8 more
europepmc   +1 more source

Paclitaxel induces NM2‐dependent cellular contraction through GEF‐H1 dissociation from microtubules and RhoA/ROCK activation in cancer cells

Molecular Oncology, EarlyView.
Taxanes are widely used chemotherapeutics whose effects on cellular mechanics remain poorly understood. We show that paclitaxel induces rapid cellular contraction by promoting GEF‐H1 dissociation from microtubules and non‐muscle myosin II activation through RhoA/ROCK.
Gloria Asensio‐Juárez, Rafael Pérez‐Díaz, Hugo Ramos‐Solano, Marina Garrido‐Casado, Vanessa C. Talayero, Miguel Vicente‐Manzanares   +5 more
wiley   +1 more source

Perceived Healthcare Interventions and Clinical Strategies Against Dating Violence: A Qualitative Exploration of Expert and Nursing Perspectives. [PDF]

Nurs Rep
Puig-Llobet M, Sanchez-Balcells S, Agüera Z, Sánchez-Ortega MA, Ventosa-Ruiz A, El-Abidi K, Vergés Bosch N, Rodriguez-Martin D, Rodríguez Ávila N, Juárez Sánchez A, Maestre E, Perau Campos M, Luque A, Martínez Bueno C, Aragón Castro L, Esteban Sanz C, Nebot Echeverria M, Rigol A, Prats-Arimon M.   +18 more
europepmc   +1 more source

APOBEC3 activity and DNA polymerase‐ε deficiency are associated with distinct IDH1 R132 hotspot mutations

Molecular Oncology, EarlyView.
Isocitrate dehydrogenase 1 (IDH1) mutations are highly recurrent in multiple human cancer types, including cholangiocarcinoma and glioma. IDH1 R132C is the most common IDH1 mutation in cholangiocarcinoma and likely arises from APOBEC3A‐ or APOBEC3B‐mediated deamination.
Kelly E. Butler, Bilal A. Lone, Ecem Unal, A. Rouf Banday   +3 more
wiley   +1 more source

Habilitation and assistive devices for persons with disabilities: a new approach to respect for human rights and inclusion. [PDF]

Front Rehabil Sci
Griffo G.
europepmc   +1 more source

p190A/ARHGAP35 and p190B/ARHGAP5 proteins in endometrial cancer: a novel cancer‐relevant paralog interplay

Molecular Oncology, EarlyView.
This study identifies ARHGAP5, in addition to the frequently mutated ARHGAP35, as significantly mutated in endometrial cancer. Mutations in both genes co‐occur and are associated with their correlated downregulation. Functional CRISPR studies show that both paralogs regulate similar pathways, including actin cytoskeleton organization.
Mathilde Pinault, Capucine Heraud, Mélissa Correia de Oliveira, Véronique Neaud, Valérie Valesco, Valérie Prouzet‐Mauleon, Béatrice Turcq, Jean‐William Dupuy, Anne‐Aurélie Raymond, Sabrina Croce, Frédéric Saltel, Valérie Lagrée, Violaine Moreau   +12 more
wiley   +1 more source

The ideology of religious stigmatization: imposed identities as a tool for constructing the national community in Kazakhstan. [PDF]

Front Sociol
Duzbayev T, Aliyarov E, Seitakhmetova N, Zhandossova S, Nurov M.   +4 more
europepmc   +1 more source