Results 251 to 260 of about 17,410,214 (348)

Association Between Type D Personality and Cardiovascular Disease History: Cross-Sectional Study. [PDF]

JMIR Cardio
Grinberg K, Sela Y.
europepmc   +1 more source

Proteasomal degradation of intracellularly expressed Amblyomin‐X limits suicide gene therapy potential in melanoma cells

FEBS Open Bio, EarlyView.
This study explores the feasibility of expressing the antitumoral protein Amblyomin‐X through a suicide gene therapy approach and investigates its intracellular fate after gene delivery. Although the gene is efficiently expressed, melanoma cells rapidly degrade the Amblyomin‐X protein via proteasome activity.
Victor Dal Posolo Cinel, Carlos DeOcesano Pereira, Aline Ramos Maia Lobba, Melissa Regina Fessel, Ana Marisa Chudzinski‐Tavassi   +4 more
wiley   +1 more source

Digital twins to accelerate target identification and drug development for immune‐mediated disorders

FEBS Open Bio, EarlyView.
Digital twins integrate patient‐derived molecular and clinical data into personalised computational models that simulate disease mechanisms. They enable rapid identification and validation of therapeutic targets, prediction of drug responses, and prioritisation of candidate interventions.
Anna Niarakis, Philippe Moingeon
wiley   +1 more source

Development and validation of a nomogram for assessing depression risk in middle-aged and elderly adults with activities of daily living dysfunction: A cross-sectional study based on CHARLS data. [PDF]

Sci Prog
Peng T, Miao R, Zeng W.
europepmc   +1 more source

Systemic dysregulation of apolipoproteins in amyotrophic lateral sclerosis serum

FEBS Open Bio, EarlyView.
Amyotrophic lateral sclerosis (ALS) is a fatal disease that damages motor neurons. This study found that people with ALS show significant changes in blood fats and the proteins that carry them. Several apolipoproteins were higher, lipid balances were altered, and normal protein–lipid relationships were disrupted.
Finula I. Isik, Russell Pickford, Hannah C. Timmins, Olivier Piguet, Glenda M. Halliday, Matthew C. Kiernan, Woojin Scott Kim   +6 more
wiley   +1 more source

The Impact of Psychological and Social Factors on Recovery After ACL Reconstruction. [PDF]

Sports Health
Malempati M, Siddiqui RN, Lo JE, Varieur BM, Rumps MV, Mulcahey MK.   +5 more
europepmc   +1 more source

Trajectories of Perinatal Depressive Symptoms from the Second Trimester to Three Months Postpartum and Their Dynamic Relationship with Social Support: A Prospective Cohort Study in Beijing, China. [PDF]

Int J Womens Health
Wang C, Hou J, Li A, Chen Y.
europepmc   +1 more source

Differential association between perceived social support and andropause symptoms by psychological distress level in employed men. [PDF]

Compr Psychoneuroendocrinol
Tanji F, Nanbu H, Kawajiri M, Nishimoto D, Akimoto T, Kurobe M.   +5 more
europepmc   +1 more source

The association of psycho-economic factors with postpartum depression without significant medical complications for the mother and infant: a systematic review and meta-analysis. [PDF]

BMC Pregnancy Childbirth
Yazdkhasti M, Kalhor M, Simbar M, Hajian S, Kiani Z, Amirian A, Ebrahimi E, Mohammadi N, Ezadi Z, Jafari M.   +9 more
europepmc   +1 more source

Are routinely collected clinical and sociodemographic characteristics associated with social functioning and activities of daily living in schizophrenia? A machine learning approach descriptive of a schizophrenia cohort. [PDF]

PLoS One
Barbalat G, Plasse J, Chéreau-Boudet I, Gouache B, Guillard-Bouhet N, Legros-Lafarge E, Franck N.   +6 more
europepmc   +1 more source