Results 31 to 40 of about 4,088,052 (198)

Brucella NyxA and NyxB dimerization enhances effector function during infection

open access: yesFEBS Letters, EarlyView.
Brucella abortus thrives inside cells thanks to the translocation of effector proteins that fine‐tune cellular functions. NyxA and NyxB are two effectors that destabilize the nucleolar localization of their host target, SENP3. We show that the Nyx proteins directly interact with each other and that their dimerization is essential for their function ...
Lison Cancade‐Veyre   +4 more
wiley   +1 more source

Urban history and modernity in Central Europe [PDF]

open access: yes, 2010
This historiographical review discusses recent literature on cities in modern Central Europe – mainly on Berlin and Vienna – which reflects the great variety of approaches to urban history and underlines the importance of urban history for the study of ...
Klautke, E.F.
core   +1 more source

The carboxylate “gripper” of the substrate is critical for C‐4 stereo‐inversion by UDP‐glucuronic acid 4‐epimerase

open access: yesFEBS Letters, EarlyView.
UDP‐glucuronic acid 4‐epimerase (UGAepi) catalyzes NAD+‐dependent interconversion of UDP‐glucuronic acid (UDP‐GlcA) and UDP‐galacturonic acid (UDP‐GalA) via C4‐oxidation, 4‐keto‐intermediate rotation, and C4‐reduction. Here, Borg et al. examined the role of the substrate's carboxylate group in the enzymic mechanism by analyzing NADH‐dependent reduction
Annika J. E. Borg   +2 more
wiley   +1 more source

Leveraging History for Faster Sampling of Online Social Networks

open access: yes, 2015
How to enable efficient analytics over such data has been an increasingly important research problem. Given the sheer size of such social networks, many existing studies resort to sampling techniques that draw random nodes from an online social network ...
Das, Gautam, Zhang, Nan, Zhou, Zhuojie
core   +1 more source

The thioredoxin‐like and one glutaredoxin domain are required to rescue the iron‐starvation phenotype of HeLa GLRX3 knock out cells

open access: yesFEBS Letters, EarlyView.
Glutaredoxin (Grx) 3 proteins contain a thioredoxin domain and one to three class II Grx domains. These proteins play a crucial role in iron homeostasis in eukaryotic cells. In human Grx3, at least one of the two Grx domains, together with the thioredoxin domain, is essential for its function in iron metabolism.
Laura Magdalena Jordt   +4 more
wiley   +1 more source

“The path of social justice”: A Human Rights History of Social Justice Education [PDF]

open access: yes, 2013
Although not often recognized, social justice education in the U.S. is historically and philosophically tied to the twentieth century\u27s human rights initiatives.
Gibson, Melissa L., Grant, Carl A.
core   +1 more source

Rethinking sport, empire, and American exceptionalism [PDF]

open access: yes, 2007
This article examines the correlation between sports history and American imperialism and exceptionalism. More specifically, the author argues against a view of sport historiography which excludes debates within social and cultural history.
Pope, Steven W.
core   +1 more source

P‐glycoprotein modulates the fluidity gradient of the plasma membrane of multidrug resistant CHO cells

open access: yesFEBS Letters, EarlyView.
To explore the impact of the overexpression of the multidrug‐transporter P‐glycoprotein (ABCB1) on membrane fluidity, we compared the transversal gradient of mobility and microviscosity in plasma membranes of drug‐sensitive Chinese hamster ovary cells (AuxB1) and their multidrug‐resistant derivatives (B30) using the fluorescent n‐(9‐anthroyloxy) fatty ...
Roger Busche   +2 more
wiley   +1 more source

The Post [PDF]

open access: yes, 2005
About the book: Asserting the need for social science historians to examine their own field, this wide-ranging volume offers an intellectual history and critical evaluation of interdisciplinary social science and social science historiography.
Vincent, David
core  

Flow‐based immunomagnetic enrichment of circulating tumor cells from diagnostic leukapheresis product

open access: yesMolecular Oncology, EarlyView.
The number of circulating tumor cells obtained from prostate cancer patients was increased approximately 5‐fold compared to regular CellSearch when processing 2 mL diagnostic leukapheresis material aliquots and increased by 44‐fold when processing 20 mL DLA aliquots using the flow enrichment target capture Halbach‐array.
Michiel Stevens   +8 more
wiley   +1 more source

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