FEBS Open Bio, EarlyView.CDT1 is an essential protein for DNA replication licensing that loads the MCM complex, the eukaryotic replicative DNA helicase, onto replication origins. Overexpression of CDT1 induces cell cycle arrest at the S phase. Here we showed CDT1 inhibits the progression of replication forks by interacting with the MCM complex, leading to the stalling and ...
Takashi Tsuyama +7 more
wiley +1 more source
Gestational diabetes mellitus complicated with depression in pregnant women: a biopsychosocial analysis and intervention strategies. [PDF]
BMC Pregnancy ChildbirthWang Y, Quan Y.
europepmc +1 more source
A general model for analysis of linear and hyperbolic enzyme inhibition mechanisms
FEBS Open Bio, EarlyView.We developed a general enzyme kinetic model that integrates these six basic inhibition mechanism onto a single one. From this model, we deduced a general enzyme kinetic equation that through modulation of simple parameters, γ (the relative inhibitor affinity for two binding sites) and β (the reactivity of the enzyme–substrate–inhibitor complex), is ...
Rafael S. Chagas, Sandro R. Marana
wiley +1 more source
Remieg Aerts, Thorbecke wil het. Biografie van een staatsman.
Tijdschrift voor Sociale en Economische Geschiedenis, 2019 Adriejan Van Veen
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Predictive role of loneliness on mortality before the age 85 years among mid- to later-life adults in the United States: a 10-year retrospective cohort study. [PDF]
Epidemiol Psychiatr SciFan HY +9 more
europepmc +1 more source
Exam‐level analysis of lecture capture viewing and student exam performance
FEBS Open Bio, EarlyView.This study asks how lecture capture relates to exam performance in biology courses with three noncumulative exams. Mixed‐effects modeling separated between‐students from within‐student effects on exam %. Students who watched more recordings earned higher grades, but viewing spikes above a student's own mean, consistent with cramming, predicted small ...
Kirk Hillsley
wiley +1 more source
The Associations Between Chronic Active Lesions and White Matter Disease: A 7 Tesla Imaging Study
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Background The relationship between paramagnetic rim lesions (PRLs) and surrounding normally appearing white matter (NAWM) disease, potentially contributory to the associations seen between PRLs and clinical impairment, is underexplored. Objectives To assess whether PRLs correlate with a greater degree of NAWM injury in early MS.
Ellie McCluey +17 more
wiley +1 more source
Contribution of the combined oral contraceptive ethinylestradiol 20 µg/dienogest 2 mg, in the treatment of mild to moderate acne vulgaris and its perceived psychological effects in young university women. [PDF]
Int J Womens DermatolPalacio-Cardona JJ +4 more
europepmc +1 more source