Results 81 to 90 of about 1,502,099 (298)

Regeneration of Dutch Urban Districts - the Role of Housing Associations [PDF]

Dutch government adopts an active policy to revitalize cities in general and to renew particular problematic housing areas in particular. In the majority of large cities the share of social housing is very large, mostly more than 50%.
Hugo Priemus
core  

Recurrent cancer‐associated ERBB4 mutations are transforming and confer resistance to targeted therapies

Molecular Oncology, EarlyView.
We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala, Sini Ahonen, Sara Peltola, Aura Tuohisto‐Kokko, Olaya Esparta, Peppi Suominen, Anne Jokilammi, Iman Farahani, Deepankar Chakroborty, Nikol Dibus, Steffen Boettcher, Tomi T. Airenne, Mark S. Johnson, Lisa D. Eli, Klaus Elenius, Kari J. Kurppa   +15 more
wiley   +1 more source

Study protocol: developing a decision system for inclusive housing: applying a systematic, mixed-method quasi-experimental design [PDF]

, 2016
Background Identifying the housing preferences of people with complex disabilities is a much needed, but under-developed area of practice and scholarship.
A Schulz, A Tong, AL Delbecq, Ali Lakhani, Australian Institute of Health and Welfare (AIHW), B Fawcett, C Cameron, C-C Leong, Clare Townsend, Courtney J. Wright, D McFadden, D McFadden, D Weisbrot, Dianne Smith, DL Morgan, EH Forman, EJ Burton, Elizabeth Kendall, GW Evans, Heidi Zeeman, HH Goldman, I Dyck, I Wiesel, IJ Chen, J Clark, J Walsh, JA Veitch, JD Kendrick, Jennifer A. Whitty, JFP Bridges, JH Hibbard, L Bond, L Bostock, L Saugeres, LL Thurstone, M Alexander, M Foster, M Herdman, M Piat, M Piat, M Ryan, M Schweitzer, MJ Liberatore, MM Shepley, MP Lawton, N Ahmed, N Welch, PricewaterhouseCoopers, Quarterly Brain Injury Services Meeting Group, R Imrie, R Johnson, R Rabin, RD Hays, RS Ulrich, S Katz, Samantha Kennerley, T Kyle, The WHOQOL Group, TL Saaty, TL Saaty, World Health Organization   +60 more
core   +2 more sources

Combining antibody conjugates with cytotoxic and immune‐stimulating payloads maximizes anti‐cancer activity

Molecular Oncology, EarlyView.
Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang, Dong Jun Koo, Peter M. Tessier, Greg M. Thurber   +3 more
wiley   +1 more source

Constructing Home and Community in Halifax Housing Cooperatives

The Journal for Undergraduate Ethnography, 2015
The subject of housing is a complex and multifaceted one in contemporary Canadian society, and urban areas in particular. Cooperative housing addresses a multitude of housing-related issues and provides an alternative model of affordable and sustainable ...
Shannon Turner, Elyssa Canning
doaj   +1 more source

Neighborhood Effects in Spatial Housing Value Models The Case of the Metropolitan Area of Paris (1999). [PDF]

In hedonic housing models, the spatial dimension of housing values are traditionally processed by the impact of neighborhood variables and accessibility variables.
Catherine Baumont and Diègo Legros
core  

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

Anchoring Equitable Development: Anchor Institute-Led Models of Housing and Community Development to Strengthen Institutions and Communities [PDF]

, 2016
In April 2014, a convening of national housing equity experts was hosted in Jacksonville, Florida by the Jessie Ball duPont Fund. The convening's purpose was to gain insight from national stakeholders on affordable housing and equitable development ...
Jason Reece, Jillian Olinger, Kareem Usher   +2 more
core  

Housing and quality of life for migrant communities in western Europe: a capabilities approach [PDF]

, 2013
Housing is an important determinant of quality of life and migrants are more likely to encounter poor quality housing than natives. This paper draws on the capabilities approach to welfare economics to examine how issues of housing and neighborhood ...
Anand, Paul, Coates, Dermot, Norris, Michelle   +2 more
core   +2 more sources

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source