Results 111 to 120 of about 3,004,220 (297)

The planar cell polarity protein Vangl2 interacts with the PDZ‐domains of Scribble but not with a unique PDZ‐like domain in Inturned

open access: yesFEBS Letters, EarlyView.
Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes   +4 more
wiley   +1 more source

Social Identification in Open Innovation Projects: Role of Knowledge Collaboration and Resource Interdependence

open access: yesSystems
In open innovation projects (OIPs), project members from different participating organizations often have dual social identifications, namely, project identification and organizational identification. While such dual identifications may align or conflict
Shaoze Fang, Yanjun Qin
doaj   +1 more source

La diversité sur le palier. Catégorisations ordinaires d’un voisinage hétérogène à Genève

open access: yesLien Social et Politiques, 2016
L’hétérogénéité de la population des centres urbains européens est souvent présentée comme une cohabitation de divers groupes (ethniques, nationaux, sociaux).
Maxime Felder
doaj   +1 more source

Tau acetylation at K331 has limited impact on tau pathology in vivo

open access: yesFEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto   +3 more
wiley   +1 more source

What are the factors which contribute to level one social work students failing to progress or achieving low grades? [PDF]

open access: yes, 2007
This article was first published in the Wolverhampton Intellectual Repository and E-Theses (WIRE). There is no printed version.This study is a preliminary review of the possible reasons for low achievement among some level one social work undergraduates.
Lees, Kate
core   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

open access: yesFEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa   +5 more
wiley   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

open access: yesFEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Identification, Screening and Stereotyping in Labour Market Discrimination [PDF]

open access: yes
According to social-psychological research, feelings of uncertainty in decision-making evoke two opposite responses: (i) reduction of uncertainty by information search, leading to less stereotyping of people, and hence less discrimination; (ii) social ...
Schwieren, Christiane, Vendrik, Maarten
core  

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