Results 111 to 120 of about 20,471,140 (259)
Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential
FEBS Letters, EarlyView.Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta +3 more
wiley +1 more source
BMC Public HealthBackground As the opioid crisis rages, maternal prescription opioid misuse (MPOM) is particularly concerning because it influences both the mother and child’s wellbeing. However, little was known about the trend of MPOM and its county-level risk factors.
Xueyi Xing +2 more
doaj +1 more source
Applied SciencesPain is a common condition among older adults and a key factor influencing daily functioning. This cross-sectional study examined how pain presence and distribution (no pain, localized pain [LP], and widespread pain [WP]) are related to limitations in ...
Diana Salas-Gómez +3 more
doaj +1 more source
Building Impact Stories: An Inspirational Guide for Communicators
This guide is designed to assist (external) communication professionals in articulating the societal impact of university activities, projects and initiatives stemming from the university’s education, research and engagement core missions and the ...
Evaluating Societal Impact
core +1 more source
FEBS Letters, EarlyView.Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas +4 more
wiley +1 more source
Frontiers in PsychologyAlzheimer’s disease (AD) causes a progressive deterioration in the person’s memory and cognitive function, leading to a greater degree of dependency as the disease progresses. This causes a progressive increase in caregiver overload, leading to physical,
Laura Muñoz-Bermejo +7 more
doaj +1 more source
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
BMC Sports Science, Medicine and RehabilitationBackground Sport-for-development (SFD) aims to use implicit features of sport (such as leadership, teamwork, and communication) to improve non-sport-related outcomes, including physical health, physical literacy, mental health, and social competency ...
Bhanu Sharma +6 more
doaj +1 more source
Journal of Public Health in AfricaBackground: Low birth weight (LBW) is a major public health concern in Lesotho, linked to higher infant mortality, long-term morbidity and intergenerational poverty. Despite expanded maternal and child health services, socio-economic disparities in birth
Topollo E. Motlamelle +1 more
doaj +1 more source
Liver organoids: modelling complexity in homeostasis and disease
FEBS Letters, EarlyView.Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley +1 more source