Results 151 to 160 of about 2,252,232 (307)
Emerging role of ARHGAP29 in melanoma cell phenotype switching
Molecular Oncology, EarlyView.This study gives first insights into the role of ARHGAP29 in malignant melanoma. ARHGAP29 was revealed to be connected to tumor cell plasticity, promoting a mesenchymal‐like, invasive phenotype and driving tumor progression. Further, it modulates cell spreading by influencing RhoA/ROCK signaling and affects SMAD2 activity. Rho GTPase‐activating protein
Beatrice Charlotte Tröster +3 more
wiley +1 more source
Did the Decline in Social Capital Depress Americans’ Happiness? [PDF]
Most popular explanations cannot fully account for the declining trend of U.S. reported well-being during the last thirty years. We test the hypothesis that the relationship between social capital and happiness at the individual level accounts for what ...
Ennio Bilancini +2 more
core
Molecular Oncology, EarlyView.In this exploratory study, we investigated the relationship between the gut microbiota and outcome in patients with metastatic hormone receptor‐positive breast cancer, treated in a randomized clinical trial with chemotherapy alone or chemotherapy in combination with immune checkpoint blockade.
Andreas Ullern +7 more
wiley +1 more source
Modeling hepatic fibrosis in TP53 knockout iPSC‐derived human liver organoids
Molecular Oncology, EarlyView.This study developed iPSC‐derived human liver organoids with TP53 gene knockout to model human liver fibrosis. These organoids showed elevated myofibroblast activation, early disease markers, and advanced fibrotic hallmarks. The use of profibrotic differentiation medium further amplified the fibrotic signature seen in the organoids.
Mustafa Karabicici +8 more
wiley +1 more source
Research on the development relationship between safety production indicators and economic and social indicators in China. [PDF]
Sci RepHan D, Fang S, Zhu H.
europepmc +1 more source
Income dynamics in three societies: an investigation of social dynamics using old and new types of social indicators [PDF]
This paper* sets out to offer new insight into social change, especially social transformation. The authors have drawn up new types of social indicators to encapsulate the nature of social change, with the intention of widening its meaning.
Habich, Roland, Spéder, Zsolt
core
Molecular Oncology, EarlyView.This study investigated how PYCR1 inhibition in bone marrow stromal cells (BMSCs) indirectly affects multiple myeloma (MM) cell metabolism and viability. Culturing MM cells in conditioned medium from PYCR1‐silenced BMSCs impaired oxidative phosphorylation and increased sensitivity to bortezomib.
Inge Oudaert +13 more
wiley +1 more source
Inequitable access to PrEP among gay, bisexual, and other men who have sex with men in Canada: A network analysis of social indicators. [PDF]
SSM Popul HealthAdam BD +7 more
europepmc +1 more source
Decomposing social indicators using distributional data [PDF]
Are the poor less healthy? Does public health spending matter more to them? The authors decompose aggregate health indicators using a random coefficients model in which the aggregates are regressed on the population distribution by subgroups, taking ...
Bidani, Benu, Ravallion, Martin
core
Molecular Oncology, EarlyView.Following high dose rate brachytherapy (HDR‐BT) for hepatocellular carcinoma (HCC), patients were classified as responders and nonresponders. Post‐therapy serum induced increased BrdU incorporation and Cyclin E expression of Huh7 and HepG2 cells in nonresponders, but decreased levels in responders.
Lukas Salvermoser +14 more
wiley +1 more source