Results 151 to 160 of about 27,680,414 (309)
Older people, social networks and information behaviour [PDF]
The study aim was to explore the information behaviour of older people living in a rural location in order to understand how they exchanged information through their social networks and social activities.
Capel, Sue
core
Molecular Oncology, EarlyView.We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober +16 more
wiley +1 more source
MITF maintains genome stability in nonmelanocyte lineages
Molecular Oncology, EarlyView.MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir +13 more
wiley +1 more source
, 2017 Introduction. Personality and trust have been found to be important precursors of information-sharing behaviour, but little is known about how these factors interact with each other in shaping information-sharing behaviour.
Li, Hongxiu +4 more
core
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization
Molecular Oncology, EarlyView.In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu +13 more
wiley +1 more source
Digested Information as an Information Theoretic Motivation for Social Interaction [PDF]
Within a universal agent-world interaction framework, based on Information Theory and Causal Bayesian Networks, we demonstrate how every agent that needs to acquire relevant information in regard to its strategy selection will automatically inject part ...
Christoph Salge, Daniel Polani
core
The Social Study administers a yearly core study questionnaire that captures essential socio-demographic, behavioral, and attitudinal information among all panel members.
The Social Study
core +1 more source
Strategy for digitalisation and information management in healthcare and social welfare
The preparation of the strategy for digitalisation and information management in healthcare and social welfare began in February 2023. The aim was to identify the strategic priorities based on the need to develop activities.
core +1 more source
Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer
Molecular Oncology, EarlyView.Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola +11 more
wiley +1 more source