Results 101 to 110 of about 477,384 (301)

An isoform of 14‐3‐3 protein regulates transbilayer lipid movement at the plasma membrane

FEBS Letters, EarlyView.
Loss of 14‐3‐3ζ in CHO cells confers resistance to exogenous phosphatidylserine (PS) and impairs endocytosis‐independent inward flip‐flop of fluorescent PS at the plasma membrane. RNAi‐mediated knockdown reproduces this defect, while no additive effect is seen in ATP11C‐deficient cells.
Akiko Yamaji‐Hasegawa, Akira Hattori, Masafumi Tsujimoto, Toshihide Kobayashi   +3 more
wiley   +1 more source

Alcohol affects neuronal substrates of response inhibition but not of perceptual processing of stimuli signalling a stop response [PDF]

, 2013
Alcohol impairs inhibitory control, including the ability to terminate an initiated action. While there is increasing knowledge about neural mechanisms involved in response inhibition, the level at which alcohol impairs such mechanisms remains poorly ...
A Green, A Hampshire, A Mehrabian, A Nambu, A Rey, AD Chevrier, AJ Caswell, AL Norman, AR Aron, AR Aron, AR Aron, AR Aron, AR Aron, BM Anderson, C Easdon, CA Marczinski, CA Marczinski, CA Marczinski, CD Chambers, CM Dodds, CM Steele, CN Boehler, CN Boehler, CN White, CR Guillot, CS Li, DJ Sharp, DM Dougherty, DM McCarthy, DM Torta, F Esposito, F Verbruggen, F Verbruggen, GD Logan, GE Alexander, GE Alexander, H de Wit, HM Duvernoy, Hugo Critchley, J Ashburner, J Chikazoe, J Weafer, JH Patton, JL Kenemans, JM Townshend, K Fromme, K Katanoda, K Marinkovic, K Nikolaou, K Rubia, KJ Friston, Kyriaki Nikolaou, L Boucher, LE Mulvihill, M Field, M Sano, MA Schuckit, Marcus Gray, MC Stevens, MT Fillmore, MT Fillmore, N Weiskopf, ND Volkow, NH Naqvi, R Deichmann, R Weissenborn, RB Buxton, RN Henson, RS Ross, RZ Goldstein, S Loeber, S Loeber, S Loeber, SC Matthews, SD Slotnick, T Duka, T Nichols, T Singer, Theodora Duka   +78 more
core   +1 more source

The ubiquitin ligase RNF115 is required for the clearance of damaged lysosomes

FEBS Letters, EarlyView.
Upon lysosomal rupture, an E3 ubiquitin ligase RNF115 translocates from the cytosol to the damaged lysosomal membrane. Moreover, RNF115 depletion impairs the clearance of damaged lysosomes, identifying it as a key regulator of lysosomal quality control.
Sae Nakanaga, Toshiki Takahashi, Akiko Kuma, Hiroyuki Kawahara   +3 more
wiley   +1 more source

Comment on “The Spreading of Disorder†[PDF]

Keizer et al. (2008) explore disorderly settings linked to a process of spreading norm violation. The results show that if norm violating behavior becomes more common, it negatively affects compliance in other areas.
Benno Torgler
core  

Common Ribs of Inhibitory Synaptic Dysfunction in the Umbrella of Neurodevelopmental Disorders

, 2018
The term neurodevelopmental disorder (NDD) is an umbrella term used to group together a heterogeneous class of disorders characterized by disruption in cognition, emotion, and behavior, early in the developmental timescale.
Hines, Rochelle M., Joya, Christina, Rodriguez, Rachel Ali   +2 more
core   +2 more sources

Psychosocial Outcomes in Long-Term Cochlear Implant Users [PDF]

, 2018
OBJECTIVES: The objectives of this study were to investigate psychosocial outcomes in a sample of prelingually deaf, early-implanted children, adolescents, and young adults who are long-term cochlear implant (CI) users and to examine the extent to ...
Castellanos, Irina, Kronenberger, William G., Pisoni, David B.   +2 more
core   +1 more source

Organizing the interface—Plasma membrane architecture and receptor dynamics in virus‐cell interactions

FEBS Letters, EarlyView.
Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley   +1 more source

A mouse model of autism implicates endosome pH in the regulation of presynaptic calcium entry. [PDF]

, 2018
Psychoactive compounds such as chloroquine and amphetamine act by dissipating the pH gradient across intracellular membranes, but the physiological mechanisms that normally regulate organelle pH remain poorly understood.
Bendor, Jacob, Edwards, Robert H, Levy, Jonathan, Nicoll, Roger A, Pham, Ellen, Seifikar, Helia, Silm, Katlin, Sohal, Vikaas S, Sullivan, Michael, Ullman, Julie C, Yang, Jing   +10 more
core   +3 more sources

AAA+ protein unfoldases—the Moirai of the proteome

FEBS Letters, EarlyView.
AAA+ unfoldases are essential molecular motors that power protein degradation and disaggregation. This review integrates recent cryo‐electron microscopy (cryo‐EM) structures and single‐molecule biophysical data to reconcile competing models of substrate translocation.
Stavros Azinas, Marta Carroni
wiley   +1 more source

The moderating effects of executive functions: A multi-level analysis of daily stress and problematic social media use

Computers in Human Behavior Reports
Mixed findings on the relationship between daily stress and social media use suggest the presence of moderators that buffer this link. Previous longitudinal studies, with assessment intervals from 1 month to 1 year, may not accurately capture daily ...
Wee Qin Ng, Hwajin Yang
doaj   +1 more source