Results 201 to 210 of about 8,448,369 (354)

Social Isolation and Loneliness [PDF]

, 2016
de Jong Gierveld, J., Tilburg, T.G. van
openaire   +4 more sources

Down‐regulation of Shh in the hair follicles of mice during chemotherapy‐induced hair loss is mediated by the JAK/STAT1 signaling pathway

FEBS Open Bio, EarlyView.
We found that during chemotherapy‐induced alopecia (CIA), Sonic hedgehog (Shh) expression significantly decreased in hair follicle Shh+ cells, whereas the Janus‐activated kinase/signal transducer and activator of transcription 1 (JAK/STAT1) signaling pathway was markedly activated.
Ruifang Fan, Jingling Huang, Xiang Lin, Tingjiao Lan, Yuli Tang, Ling Sun, Guixuan Zhou   +6 more
wiley   +1 more source

FGFR Like1 drives esophageal cancer progression via EMT, PI3K/Akt, and notch signalling: insights from clinical data and next‐generation sequencing analysis

FEBS Open Bio, EarlyView.
Clinical analysis reveals significant dysregulation of FGFRL1 in esophageal cancer (EC) patients. RNAi‐coupled next‐generation sequencing (NGS) and in vitro study reveal FGFRL1‐mediated EC progression via EMT, PI3K/Akt, and Notch pathways. Functional assays confirm its role in tumor growth, migration, and invasion.
Aprajita Srivastava, Anoop Saraya, Deepak Gunjan, Rinu Sharma   +3 more
wiley   +1 more source

Evaluation of in vitro toxicity of common phytochemicals included in weight loss supplements using 1H NMR spectroscopy

FEBS Open Bio, EarlyView.
We investigated the toxicity of 12 active compounds commonly found in herbal weight loss supplements (WLS) using human liver and colon cell models. Epigallocatechin‐3‐gallate was the only compound showing significant toxicity. Metabolic profiling revealed protein degradation, disrupted energy and lipid metabolism suggesting that the inclusion of EGCG ...
Emily C. Davies, Garth L. Maker, Ian F. Musgrave, Samantha Lodge   +3 more
wiley   +1 more source

Toward the Development of an IAT to Measure Potential Social Isolation

Shotaro Shizawa, Naoaki Kawakami, Takashi Arai, Y. Honda, Miyuki Aiba, Daichi Sugawara, Yuki Shiratori, Hirokazu Tachikawa   +7 more
openalex   +2 more sources

Influence of co-existing social isolation and homebound status on medical care utilization and expenditure among older adults in Japan

, 2020
Seigo Mitsutake, Takashi Koike, Tatsuro Ishizaki, Ryota Sakurai, Masashi Yasunaga, Mariko Nishi, Taro Fukaya, Erika Kobayashi, Hiroyuki Suzuki, Kumiko Nonaka, Masashige Saito, Masami Hasebe, Yoh Murayama, Yoshinori Fujiwara   +13 more
openalex   +2 more sources

KLK7 overexpression promotes an aggressive phenotype and facilitates peritoneal dissemination in colorectal cancer cells

FEBS Open Bio, EarlyView.
KLK7, a tissue kallikrein‐related peptidase, is elevated in advanced colorectal cancer and associated with shorter survival. High KLK7 levels in ascites correlate with peritoneal metastasis. In mice, KLK7 overexpression increases metastasis. In vitro, KLK7 enhances cancer cell proliferation, migration, adhesion, and spheroid formation, driving ...
Yosr Z. Haffani, Tobias Dreyer, Meriem Naim, Rea Lo Dico, Natalia A. Ignatenko, Viktor Magdolen, Dalila Darmoul   +6 more
wiley   +1 more source

Pearson correlation coefficients between PTPS results and well-being, psychological distress, social isolation, and job satisfaction.

Takeshi Miura (206901), Koji Hara (8158500), Azusa Arimoto (7025822), Masato Kaneko (20978609), Sayuri Shiraishi (20978612), Shingo Matsumura (20978615), Shuichi Ito (3179127), Kentaro Kurasawa (20978618), Yohei Matsuzaki (20978621), Makoto Kuroki (11468715)   +9 more
openalex   +1 more source

Pioglitazone plus (−)‐epigallocatechin gallate: a novel approach to enhance osteogenic performance in aged bone marrow mesenchymal stem cells

FEBS Open Bio, EarlyView.
Aged human bmMSCs are seeded in the scaffold. Osteoblastic induction can slightly increase cell's bone‐forming activity to produce bone‐like tissues, shown as the sporadic xylenol orange‐stained spots (the lower left image). Notably, pioglitazone plus EGCG co‐treatment dramatically increases cell's bone‐forming activity and bone‐like tissue production (
Ching‐Yun Chen, Jia‐Ci Jhang, Chun‐Yi Peng, Quốc Cường Nguyễn, Feng‐Huei Lin, Hung‐Ming Wu, Shankung Lin   +6 more
wiley   +1 more source

Social Isolation in Turkish Adolescents: Translation, Cross-Cultural Adaptation, and Validation of the Social Isolation Questionnaire. [PDF]

Children (Basel)
Çevik Özdemir HN, Ayran G.
europepmc   +1 more source