Results 151 to 160 of about 1,489,546 (268)

Interpreting the effects of DNA polymerase variants at the structural level

Molecular Oncology, EarlyView.
Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi, Karolina Krzesińska, Ludovica Beltrame, Pablo Sánchez‐Izquierdo Besora, Matteo Tiberti, Mef Nilbert, Anna Rohlin, Elena Papaleo   +7 more
wiley   +1 more source

Ethical, legal, and social issues of AI use in emergency healthcare: a scoping review. [PDF]

BMC Med Inform Decis Mak
Lim JE, Siddiqui FJ, Ballantyne A, Dunn M, Prince S, Wilkinson D, Lewis J, Yoon S, Savulescu J, Schaefer GO.   +9 more
europepmc   +1 more source

Media portrayal of ethical and social issues in brain organoid research. [PDF]

Philos Ethics Humanit Med, 2022
Presley A, Samsa LA, Dubljević V.
europepmc   +1 more source

This is What Women Want: A Speak-Out the Issues and Views for the Presidential Election

, 2008
Includes descriptive metadata provided by producer in MP4 file: "Politics, Economics and Social Issues - Video - This is What Women Want: A Speak-Out the Issues and Views for the Presidential Election." Women activists participate in a speak-out on ...
Nixon, Betty, Meeker, Judith Biondo, Rawls, Jennifer, Jones, Sherry   +3 more
core  

DNA methylation and expression of MAPRE3 affect overall survival of early‐stage non‐small cell lung cancer patients

Molecular Oncology, EarlyView.
Both cg12821679MAPRE3 methylation and MAPRE3 expression are significantly associated with overall survival (OS) of non‐small cell lung cancer. Meanwhile, MAPRE3 expression significantly modified the effect of smoking cessation on OS. Smoking cessation benefits OS merely for patients with high MAPRE3 expression.
Chao Chen, Jiancheng Cheng, Ruili Hou, Xiaoyuan Zheng, Li Su, Maria Moksnes Bjaanæs, Anna Karlsson, Maria Planck, Johan Staaf, Åslaug Helland, Manel Esteller, David C. Christiani, Feng Chen, Xiaofei Cao, Ruyang Zhang   +14 more
wiley   +1 more source

Women's Health, Social Issues, and Quality of Care in Family Medicine. [PDF]

J Am Board Fam Med
Bowman MA, Tietbohl CK, Seehusen DA, Ledford CJW.   +3 more
europepmc   +1 more source

Ethical, legal, and social issues in the Earth BioGenome Project. [PDF]

Proc Natl Acad Sci U S A, 2022
Sherkow JS, Barker KB, Braverman I, Cook-Deegan R, Durbin R, Easter CL, Goldstein MM, Hudson M, Kress WJ, Lewin HA, Mathews DJH, McCarthy C, McCartney AM, da Silva M, Torrance AW, Greely HT.   +15 more
europepmc   +1 more source

Circulating tumor cell viability during and after radiotherapy mirrors treatment response in cancer patients

Molecular Oncology, EarlyView.
Radiotherapy (RT) response depends on the DNA repair capacity of tumor and host cells. We show that circulating tumor cell (CTC) counts and apoptosis rates before and after RT predict treatment response and outcome, which can be accessed via easily accessible liquid biopsy approaches. Created in BioRender. Wikman, H.
Yvonne Goy, Jana Löptien, Cornelia Coith, Afroditi Nanou, Katharina Hintelmann, Pinnschmidt Hans, Cordula Petersen, Klaus Pantel, Sabine Riethdorf, Kerstin Borgmann, Harriet Wikman   +10 more
wiley   +1 more source

Addressing Ethical, Legal, and Social Issues on Artificial Intelligence Together With Patients' Perspectives: Prerequisites for Responsible Social Implementation in Endoscopy. [PDF]

Dig Endosc
Tsuji Y, Fujishiro M.
europepmc   +1 more source

Digital Covid Certificates as Immunity Passports: An Analysis of Their Main Ethical, Legal, and Social Issues. [PDF]

J Bioeth Inq, 2022
de Miguel Beriain Í, Rueda J.
europepmc   +1 more source