Results 81 to 90 of about 10,449,652 (350)

Subtype‐specific enhancer RNAs define transcriptional regulators and prognosis in breast cancers

Molecular Oncology, EarlyView.
This study employed machine learning methodologies to perform the subtype‐specific classification of RNA‐seq data sets, which are mapped on enhancers from TCGA‐derived breast cancer patients. Their integration with gene expression (referred to as ProxCReAM eRNAs) and chromatin accessibility profiles has the potential to identify lineage‐specific and ...
Aamena Y. Patel, Peyman Zarrineh, Nathnael T. Tuffa, Jigar H. Sheth, Sumitra Mohan, Mudassar Iqbal, Sankari Nagarajan   +6 more
wiley   +1 more source

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

Molecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova   +25 more
wiley   +1 more source

Social Justice and the Arts [PDF]

, 2015
This document is designed to provide a concise, but representative sampling of the many arts programs, projects, networks, and individuals involved in creative, progressive change in their diverse communities.
Dewald, J. A.
core   +1 more source

Political feasibility of 1.5°C societal transformations: the role of social justice

, 2018
Constraining global climate change to 1.5°C is commonly understood to require urgent and deep societal transformations. Yet such transformations are not always viewed as politically feasible; finding ways to enhance the political feasibility of ambitious
James Patterson, T. Thaler, M. Hoffmann, S. Hughes, Angela Oels, E. Chu, A. Mert, D. Huitema, S. Burch, A. Jordan   +9 more
semanticscholar   +1 more source

Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma

Molecular Oncology, EarlyView.
The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic, Anne Nørremølle, Lilian Bomme Ousager, Lars van Brakel Andersen, Marie Louise Mølgaard Binderup, Mads Thomassen   +5 more
wiley   +1 more source

Justice Delayed in the COVID-19 Era: Injunctions, Mootness, and Religious Freedom in the United States Legal System

Laws
The COVID-19 pandemic exposed critical deficiencies in the United States’ legal system’s handling of emergency injunctions, particularly concerning religious freedom.
Karen McGuffee, Tammy Garland, Sherah L. Basham   +2 more
doaj   +1 more source

Social Justice and Development

, 2008
Poverty is quintessentially an issue of inequality or lack of social justice within and between nation states. And yet mainstream development theory and institutions of global governance continue to couch reducing poverty as a policy objective, rather than focus on underlying issues of inequality.
openaire   +2 more sources

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source

The arc of the moral universe bends towards justice : evangelical Christians engaging with social justice : a thesis presented in partial fulfilment of the requirements for the degree of Master of Arts in Social Anthropology at Massey University, Palmerston North, New Zealand [PDF]

, 2016
This research explores how young evangelical Christians frame the concept of social justice, in particular relating to human trafficking. In the last fifteen years there has been a considerable increase in the number of Evangelicals who are becoming ...
Rivera-Puddle, Catherine
core  

Social Justice Begins at Home: The Challenges and Successes of a Social Justice Living-Learning Community [PDF]

, 2012
This article describes the development of the Dorothy Day Social Justice Community, a sophomore, social justice-focused living–learning community at Marquette University.
Dowdy, Renee Piquette, Janz, Mary, Jessup-Anger, Jody   +2 more
core   +2 more sources