Results 41 to 50 of about 4,011,023 (299)

KLK7 overexpression promotes an aggressive phenotype and facilitates peritoneal dissemination in colorectal cancer cells

FEBS Open Bio, EarlyView.
KLK7, a tissue kallikrein‐related peptidase, is elevated in advanced colorectal cancer and associated with shorter survival. High KLK7 levels in ascites correlate with peritoneal metastasis. In mice, KLK7 overexpression increases metastasis. In vitro, KLK7 enhances cancer cell proliferation, migration, adhesion, and spheroid formation, driving ...
Yosr Z. Haffani, Tobias Dreyer, Meriem Naim, Rea Lo Dico, Natalia A. Ignatenko, Viktor Magdolen, Dalila Darmoul   +6 more
wiley   +1 more source

Hidden and uninterested populations: Methodological insights and unresolved issues from the study of Cannabis Social Clubs

Methodological Innovations, 2020
Cannabis Social Clubs are typically non-profit associations established by adult users of cannabis, which produce and distribute cannabis among their members.
Mafalda Pardal, Melissa Bone, Tom Decorte, Rosario Queirolo, Òscar Parés, Julia Johansson, Eliana Álvarez, Lorena Repetto   +7 more
doaj   +1 more source

Collecting survey data among the 50+ population during the COVID-19 outbreak: The Survey of Health, Ageing and Retirement in Europe (SHARE)

Survey Research Methods, 2020
While the COVID-19 crisis resulted in a vast number of new research projects springing up like mushrooms everywhere, it had severe consequences for ongoing survey research and in particular for running data collections.
Annette Scherpenzeel, Kathrin Axt, Michael Bergmann, Salima Douhou, Andrea Oepen, Gregor Sand, Karin Schuller, Stephanie Stuck, Melanie Wagner, Axel Börsch-Supan   +9 more
doaj   +1 more source

Local Self-Government Transformations in Ukraine and Reforms of Social Services: Expectations and Challenges [PDF]

, 2020
On January 1, 2020, the Law “On Social Services” comes into force in Ukraine. The new legislation sets up the responsibilities for the executive bodies of city councils, councils of cities of regional significance, councils of united territorial ...
Semigina, Tetyana
core   +2 more sources

Applying an Ethical Lens to the Treatment of People With Multiple Sclerosis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT The practice of neurology requires an understanding of clinical ethics for decision‐making. In multiple sclerosis (MS) care, there are a wide range of ethical considerations that may arise. These involve shared decision‐making around selection of a disease‐modifying therapy (DMT), risks and benefits of well‐studied medications in comparison to
Methma Udawatta, Farrah J. Mateen
wiley   +1 more source

Brainstem and Cerebellar Volume Loss and Associated Clinical Features in Progressive Supranuclear Palsy

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Introduction Progressive Supranuclear Palsy (PSP) is a neurodegenerative ‘tauopathy’ with predominating pathology in the basal ganglia and midbrain. Caudal tau spread frequently implicates the cerebellum; however, the pattern of atrophy remains equivocal.
Chloe Spiegel, Timothy P. Siejka, Cassandra Marotta, Josh J. Y. Lee, Kelly Bertram, Terence J. O'Brien, Meng Law, Lucy Vivash, Ian H. Harding   +8 more
wiley   +1 more source

Fluid Biomarkers of Disease Burden and Cognitive Dysfunction in Progressive Supranuclear Palsy

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Identifying objective biomarkers for progressive supranuclear palsy (PSP) is crucial to improving diagnosis and establishing clinical trial and treatment endpoints. This study evaluated fluid biomarkers in PSP versus controls and their associations with regional 18F‐PI‐2620 tau‐PET, clinical, and cognitive outcomes.
Roxane Dilcher, Charles B. Malpas, Stuart J. McDonald, William T. O’Brien, Craig Despott, Kelly L. Bertram, Matthew P. Pase, Lukas Frontzkowski, Meng Law, Terence J. O’Brien, Lucy Vivash   +10 more
wiley   +1 more source

New Interpretation of Social Needs in Hungarian Law

Stanovništvo
The Hungarian legislator's approach to means-tested social benefits is complex, often focusing on reducing expenditures. The emergence of new social and family support benefits has somewhat overshadowed these traditional benefits, with substantive ...
Gábor Mélypataki
doaj   +1 more source

Creeping Impoverization: Material Conditions, Income Inequality, And ERISA Pedagogy Early In The 21st Century [PDF]

, 2007
This Essay argues that the current trend focusing on the law and economics theory does a disservice to the full-spectrum of legal issues. Law and economics, according to the author, is a value -neutral approach to the law.
Hylton, Maria O\u27Brien
core   +1 more source

​Did a Non‐Medical Biosimilar Switching Policy Cause an Increase in Non‐Biologic/Biosimilar Health Care Resource Utilization or Cost in Patients With Inflammatory Arthritis?

Arthritis Care &Research, EarlyView.
Objective This study aimed to evaluate the impact of a series of policies that mandated switching patients with inflammatory arthritis (IA) from an originator biologic to a biosimilar in British Columbia, Canada, on health care resource use and cost.
HaoHung Dang, Sandra Blitz, Nick Bansback, Michael Law, Mark Harrison   +4 more
wiley   +1 more source