Results 111 to 120 of about 21,596,592 (299)

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

Middle managers in Scotland’s social services: A scoping analysis for the Scottish Social Services Council by University of Stirling

, 2014
In this report we start by setting the context for our scoping analysis of the role and functions of middle managers in Scotland's social services. Within this section, we discuss the challenge of identifying ‘who is a middle manager' and whether ...
Patterson, Frances, George, Carol
core  

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

Molecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park, Kyongman An, Gyeonghwa Kim, Soo‐Nyun Choi, Hong‐Ki Lee, Keun Hur, Kyu‐Shik Jeong   +6 more
wiley   +1 more source

Cancer‐associated mutations in endometriosis reframe a benign disease through molecular oncology

Molecular Oncology, EarlyView.
This review aims to comprehensively analyse cancer‐associated somatic mutations (CAMs) present in endometriotic lesions, emphasizing their biological roles, spatial distribution and implications for translational applications in medicine. By contextualizing a benign state within a genomic framework, this analysis seeks to establish its value as a ...
Clarissa Mujacic, Maria Concetta Vitale, Rita Siino, Emilia Di Giovanni, Carla Ferrante Bannera, Enrico Di Marco, Andrea Gottardo, Tancredi Didier Bazan Russo, Nadia Barraco, Alessandro Perez, Valerio Gristina, Antonio Galvano, Giuseppe Badalamenti, Antonio Russo, Viviana Bazan, Lorena Incorvaia   +15 more
wiley   +1 more source

Os Conselhos Municipais de Políticas Públicas sob o Olhar da Comunidade: Uma Experiência de Extensão Universitária

Desenvolvimento em Questão, 2012
Based on the relationship between social management and university extension in a freiriana perspective, this article intends to analyze an extension initiative while an instrument for the awareness of the community concerning the importance of the ...
Thais Soares Kronemberger, Fernando Guilherme Tenório, Anderson Felisberto Dias, Ana Clara Rodrigues Barros   +3 more
doaj  

The organization's social environment

Известия высших учебных заведений: Социология. Экономика. Политика
Several factors contributed to the importance of the study of social environment. These factors include enhancing employee motivation, reducing turnover, and retaining valuable staff; increasing customer and companies-partners loyalty; practical effects ...
A. L. Skifskaya, A. S. Gyurdzhinyan
doaj   +1 more source

EARNINGS MANAGEMENT AND CORPORATE SOCIAL RESPONSIBILITY [PDF]

Drawing on stakeholder-agency theory and the earnings management framework, we explore the relationship between discretionary accounting accruals and corporate social responsibility.
Jordi Surroca, Diego Prior, Josep A. Tribo   +2 more
core  

Preoperative circulating tumor cells integrated with imaging analysis for prognostic evaluation in head and neck squamous cell carcinoma

Molecular Oncology, EarlyView.
Detecting circulating tumor cells (CTCs) in blood before surgery may help predict outcomes in patients with head and neck squamous cell carcinoma (HNSCC). Here, we show when combined with tumor size and lymph node involvement from routine imaging, CTC status identifies high‐risk patients with poorer survival—offering a simple, minimally invasive tool ...
Susanne Flach, Gizem Abaci, Tom Huberty, Axel Lechner, Lukas Käsmann, Jens Ricke, Sophia Stöcklein, Martin Canis, Philipp Baumeister, Marianna Alunni‐Fabbroni   +9 more
wiley   +1 more source

The impact of humor on teachers’ classroom management practice: scoping review of qualitative and quantitative evidence

Cogent Education
Background Humor is widely recognized as a classroom resource, yet its role in teachers’ management practices remains underexplored.Purpose This scoping review synthesizes existing research to clarify the role of humor in classroom management and ...
Martin Stokke
doaj   +1 more source

Blended pedagogy : perspectives on social entrepreneurship teaching and practice

, 2022
Social entrepreneurs are considered ‘change agents’ in the social sector, adopting a mission to create and sustain social value (Chell 2007). They recognise and pursue new opportunities to serve that mission and engage in continuous innovation, adaption ...
Succarie, Ayda (R18566), Lyne, Isaac (R19383)   +1 more
core