Results 121 to 130 of about 6,321,139 (306)

Effective therapeutic targeting of CTNNB1‐mutant hepatoblastoma with WNTinib

open access: yesMolecular Oncology, EarlyView.
WNTinib, a Wnt/CTNNB1 inhibitor, was tested in hepatoblastoma (HB) experimental models. It delayed tumor growth and improved survival in CTNNB1‐mutant in vivo models. In organoids, WNTinib outperformed cisplatin and showed enhanced efficacy in combination therapy, supporting its potential as a targeted treatment for CTNNB1‐mutated HB.
Ugne Balaseviciute   +17 more
wiley   +1 more source

Hikester - the event management application

open access: yes, 2018
Today social networks and services are one of the most important part of our everyday life. Most of the daily activities, such as communicating with friends, reading news or dating is usually done using social networks.
Khatipov, Rinat   +5 more
core   +1 more source

Monitoring of circulating tumor DNA allows early detection of disease relapse in patients with operable breast cancer

open access: yesMolecular Oncology, EarlyView.
Monitoring circulating tumor DNA (ctDNA) in patients with operable breast cancer can reveal disease relapse earlier than radiology in a subset of patients. The failure to detect ctDNA in some patients with recurrent disease suggests that ctDNA could serve as a supplement to other monitoring approaches.
Kristin Løge Aanestad   +35 more
wiley   +1 more source

HUMANIZING OF ADMINISTRATIVE ACTIVITY

open access: yesНаучный вестник МГТУ ГА, 2016
The article deals with determining the basic directions of humanizing the administrative activity in organization the content of which provides a constructive dialog in the «leader-subordinate» system based on taking into account of many-sided nature of ...
O. D. Garanina, A. A. Fedyashov
doaj  

Assessing spatial information access, use and sharing for catchment management in Australia [PDF]

open access: yes, 2011
Spatial data plays an important role in many social, environmental, economic and political decisions and is increasingly acknowledged as a national resource essential for sustainable development.
Apan, Armando   +2 more
core  

LINC01116, a hypoxia‐lncRNA marker of pathological lymphangiogenesis and poor prognosis in lung adenocarcinoma

open access: yesMolecular Oncology, EarlyView.
The LINC01116 long noncoding RNA is induced by hypoxia and associated with poor prognosis and high recurrence rates in two cohorts of lung adenocarcinoma patients. Here, we demonstrate that besides its expression in cancer cells, LINC01116 is markedly expressed in lymphatic endothelial cells of the tumor stroma in which it participates in hypoxia ...
Marine Gautier‐Isola   +12 more
wiley   +1 more source

Intellectual evolution of strategic management and its relationship with ethics and social responsibility [PDF]

open access: yes
The main purpose here is to present an overview of the historical development of strategic management, through a critical review of the most relevant theoretical proposals, and to consider its links to ethics and corporate social responsibilities.
Guillen, Manuel, Melé, Domenec
core  

Developing evidence‐based, cost‐effective P4 cancer medicine for driving innovation in prevention, therapeutics, patient care and reducing healthcare inequalities

open access: yesMolecular Oncology, EarlyView.
The cancer problem is increasing globally with projections up to the year 2050 showing unfavourable outcomes in terms of incidence and cancer‐related deaths. The main challenges are prevention, improved therapeutics resulting in increased cure rates and enhanced health‐related quality of life.
Ulrik Ringborg   +43 more
wiley   +1 more source

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