Results 101 to 110 of about 20,051,300 (204)

Social enterprise: theoretical basis and perespectives [PDF]

open access: yesИкономика и компютърни науки, 2017
Since the 1980s the issues of social enterprises have gained particular popularity, practical and applied, as well as scientific significance. For a short period of time - almost half a century - social enterprises have become an integral part of ...
Julian Narlev
doaj  

Transcriptional profiling of circulating extracellular vesicles from prebiopsy prostate cancer patients

open access: yesMolecular Oncology, EarlyView.
RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner   +14 more
wiley   +1 more source

Os Conselhos Municipais de Políticas Públicas sob o Olhar da Comunidade: Uma Experiência de Extensão Universitária

open access: yesDesenvolvimento em Questão, 2012
Based on the relationship between social management and university extension in a freiriana perspective, this article intends to analyze an extension initiative while an instrument for the awareness of the community concerning the importance of the ...
Thais Soares Kronemberger   +3 more
doaj  

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

open access: yesMolecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska   +13 more
wiley   +1 more source

GESTAo DE pOLíTICA PÚBLICA DE GERACAO DE TRABALHO E RENDA: uma análise do programa nacional de incubadoras de cooperativas populares

open access: yesRevista de Políticas Públicas, 2013
This work aims to identify and analyze the main characteristics of the conduction undertaken management form the "National Program 01 Popular Cooperative Incubators" (Proninc - Programa Nacional de Incubadoras de Cooperativas Populares).
Elisangela Abreu Natividade   +2 more
doaj  

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

open access: yesMolecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura   +19 more
wiley   +1 more source

A ADMINISTRAÇÃO PÚBLICA SOCIETAL: um instrumento de controle e participação social

open access: yesRevista de Políticas Públicas, 2018
Post-social states have been glimpsed throughout the world in recent decades. In these states, fundamental rights, such as freedom, gain broader meaning through management models that provide society with eRective forms of parti- cipation.
Marcus Vinicius Gonçalves da Silva   +5 more
doaj  

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

open access: yesMolecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka   +9 more
wiley   +1 more source

Succession planning : developing management potential in a social services department [PDF]

open access: yes, 2006
This paper describes a best-practice initiative designed to develop management potential in a local authority social services department. Entitled 'the aspiring managers' programme', it aimed to assist the department with its succession planning using ...
Chick, Neil, Hafford-Letchfield, Trish
core   +1 more source

Neoliberal management of social work in Sweden

open access: yes, 2018
The neo-liberal shift in the Swedish welfare system has entailed different types of power regimes operating through human bodies – through constant processes of surveillance and discipline, including measurement and documentation.
Herz, Marcus, Lalander, Philip
core  

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