Results 91 to 100 of about 1,218,468 (265)

GESTAo DE pOLíTICA PÚBLICA DE GERACAO DE TRABALHO E RENDA: uma análise do programa nacional de incubadoras de cooperativas populares

open access: yesRevista de Políticas Públicas, 2013
This work aims to identify and analyze the main characteristics of the conduction undertaken management form the "National Program 01 Popular Cooperative Incubators" (Proninc - Programa Nacional de Incubadoras de Cooperativas Populares).
Elisangela Abreu Natividade   +2 more
doaj  

Modulation of Homer1 EVH1 domain internal dynamics by putative autism‐associated mutations

open access: yesFEBS Letters, EarlyView.
The putative autism‐associated M65I and S97L variants of the EVH1 domain of the postsynaptic scaffold protein Homer1 do not exhibit substantial changes in their overall structure or partner binding. Both of them, but especially the M65I variant, show altered internal dynamics relative to the wild‐type domain on the μs‐ms timescale, indicated by the ...
Fanni Farkas   +6 more
wiley   +1 more source

A ADMINISTRAÇÃO PÚBLICA SOCIETAL: um instrumento de controle e participação social

open access: yesRevista de Políticas Públicas, 2018
Post-social states have been glimpsed throughout the world in recent decades. In these states, fundamental rights, such as freedom, gain broader meaning through management models that provide society with eRective forms of parti- cipation.
Marcus Vinicius Gonçalves da Silva   +5 more
doaj  

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

open access: yesFEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

Environmental management of social dilemas

open access: yesEuropean Spatial Research and Policy, 1995
Social dilemmas are contradictions between the interests of individuals and the collective interests as expressed in plans and policy proposals. It is argued in this paper that if these social dilemmas are denied in environmental planning then this may have detrimental consequences in the long run for urban ecology and society.
openaire   +3 more sources

Three phosphatase families form a community: The phosphohydrolases that act upon inositol pyrophosphates

open access: yesFEBS Letters, EarlyView.
Inositol pyrophosphates are energy‐rich signaling molecules that perform critical functions in cells. Three different families of phosphatases hydrolyze the β phosphate of the inositol pyrophosphate molecules: two have narrow specificities and one is promiscuous.
Ronda J. Rolfes
wiley   +1 more source

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

open access: yesMolecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce   +11 more
wiley   +1 more source

Transcriptional profiling of circulating extracellular vesicles from prebiopsy prostate cancer patients

open access: yesMolecular Oncology, EarlyView.
RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner   +14 more
wiley   +1 more source

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